2024
The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats
Terreros G, Pérez M, Muñoz-LLancao P, D’Espessailles A, Martínez E, Dagnino-Subiabre A. The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats. Nutrients 2024, 16: 381. PMID: 38337665, PMCID: PMC10857380, DOI: 10.3390/nu16030381.Peer-Reviewed Original ResearchConceptsStressed ratsInfluence anxiety-like behaviorStress-induced dendritic atrophyVulnerability to chronic stressRat chowAnxiety-like behaviorChronically stressed ratsRestraint stress protocolNon-stressedLocomotor activitySpatial memoryY-mazeCognitive performanceHippocampal morphologyMale Sprague-Dawley ratsDendritic atrophyChronic stressPrepubertal male Sprague-Dawley ratsStress protocolNeuroprotective roleSprague-Dawley ratsDendritic lengthCA3 areaPyramidal neuronsBrain physiology
2017
Upregulation of Epac-1 in hepatic stellate cells by Prostaglandin E2 in liver fibrosis is associated with reduced fibrogenesis.
Schippers M, Beljaars L, Post E, Lotersztajn S, Reker-Smit C, Han B, Munoz-Llancao P, Schmidt M, Poelstra K. Upregulation of Epac-1 in hepatic stellate cells by Prostaglandin E2 in liver fibrosis is associated with reduced fibrogenesis. Journal Of Pharmacology And Experimental Therapeutics 2017, 363: jpet.117.241646. PMID: 28864467, DOI: 10.1124/jpet.117.241646.Peer-Reviewed Original ResearchConceptsEpac-1 activationEpac-1Hepatic stellate cellsNiflumic acidPlatelet-derived growth factor-induced proliferationLiver fibrosisFibrotic livers of miceReduced Rho-kinase activityKupffer cellsIsolated hepatic stellate cellsStellate cellsCAMP-mediated effectsGrowth factor-induced proliferationWeeks carbon tetrachlorideEffect of PGE<sub>2</sub> onEPAC-1 expressionKinase activityProtein kinase A expressionRho-kinase activityWestern blot analysisActivity in vitroProstaglandin E<sub>2</sub>Cyclo-oxygenase productsDownstream targetsCell-specific delivery
2015
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc'h F, Schmidt M, González-Billault C. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Journal Of Neuroscience 2015, 35: 11315-11329. PMID: 26269639, PMCID: PMC6605123, DOI: 10.1523/jneurosci.3645-14.2015.Peer-Reviewed Original ResearchConceptsNeuronal polarityAcquisition of neuronal polarityAxon specificationGenetic manipulationRap1b activationExchange proteinGuanine exchange factorKnock-outEpac signalingRegulate neuronal polarityProtein kinase A.Axon determinationRap GTPasesWild-type neuronsExchange factorActivation of protein kinase A.Polarity defectsMouse neuronsRat hippocampal neuronsMessenger cAMPMolecular eventsEpacMature axonsCAMP-dependent mechanismPharmacological inhibition
2009
Effect of the environment on the dendritic morphology of the rat auditory cortex
Bose M, Muñoz‐llancao P, Roychowdhury S, Nichols J, Jakkamsetti V, Porter B, Byrapureddy R, Salgado H, Kilgard M, Aboitiz F, Dagnino‐Subiabre A, Atzori M. Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse 2009, 64: 97-110. PMID: 19771593, PMCID: PMC2830877, DOI: 10.1002/syn.20710.Peer-Reviewed Original ResearchConceptsApical dendritic lengthBasal dendritic lengthApical dendritesDendritic lengthAuditory cortexSpine densityBasal dendritesShorter apical dendritesGolgi-Cox staining techniqueLayer-specific patternRat auditory cortexShort basal dendritesPrimary auditory cortexSensory deafnessInduce similar changesInfragranular neuronsLayer 2/3Neocortical plasticityExcitatory synapsesSholl analysisEnvironmental enrichmentStressed animalsGolgi-CoxStress-induced changesEnvironmental manipulationsChronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
Dagnino-Subiabre A, Muñoz-Llancao P, Terreros G, Wyneken U, Díaz-Véliz G, Porter B, Kilgard M, Atzori M, Aboitiz F. Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning. Behavioural Brain Research 2009, 203: 88-96. PMID: 19397934, DOI: 10.1016/j.bbr.2009.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAnimalsAuditory PerceptionConditioning, ClassicalDendritesEscape ReactionFearFreezing Reaction, CatalepticGeniculate BodiesMaleNeuronsPhotic StimulationPosterior Thalamic NucleiRandom AllocationRatsRats, Sprague-DawleyReflex, StartleRestraint, PhysicalStress, PsychologicalVisual PerceptionConceptsMedial geniculate nucleusPosterior thalamic nucleusDendritic atrophyUnconditioned fearFear conditioningChronic stressStressed animalsAuditory conditioned stimulusAuditory fear conditioningAvoidance conditioned responseChronic restraint stressCued fear conditioningGeniculate nucleusSprague-Dawley ratsVisual fear conditioningFear conditioning protocolRestraint stressInferior colliculusThalamic nucleiConditioned stimulusConditioning trialsConditioned responseConditioning protocolUnconditioned responseAtrophy