2019
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, Aguilar O, Leslie C, Carlyle J, Sun J, O’Sullivan T. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature Immunology 2019, 20: 1004-1011. PMID: 31263280, PMCID: PMC6697419, DOI: 10.1038/s41590-019-0430-1.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsTissue-resident innate lymphoid cellsType 1 innate lymphoid cellsMouse cytomegalovirusMemory lymphocyte responsesResolution of infectionTissue-resident sentinelsPathogen-derived antigensEarly host protectionLymphocyte responsesBystander activationProinflammatory cytokinesHeterologous infectionsMCMV infectionEffector responsesSecondary challengeHost protectionLymphoid cellsMemory responsesInfectionInitial sitePresent studyPhenotypic changesResponseILC1s
2017
ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
Weizman O, Adams N, Schuster I, Krishna C, Pritykin Y, Lau C, Degli-Esposti M, Leslie C, Sun J, O’Sullivan T. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell 2017, 171: 795-808.e12. PMID: 29056343, PMCID: PMC5687850, DOI: 10.1016/j.cell.2017.09.052.Peer-Reviewed Original ResearchConceptsImmune cellsViral infectionType 1 innate lymphoid cellsInitial antiviral responseInnate lymphoid cellsTissue-resident lymphocytesConventional dendritic cellsInnate immune cellsSite of infectionEarly antiviral immunityEarly host protectionViral burdenDendritic cellsViral loadProinflammatory cytokinesPrimary infectionAntiviral immunityHost protectionLymphoid cellsHost immunityInitial infectionAntiviral responseInfectionSTAT4-dependent mannerInitial site
2016
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
O’Sullivan T, Rapp M, Fan X, Weizman O, Bhardwaj P, Adams N, Walzer T, Dannenberg A, Sun J. Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity 2016, 45: 428-441. PMID: 27496734, PMCID: PMC5004886, DOI: 10.1016/j.immuni.2016.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBasic-Leucine Zipper Transcription FactorsCell DifferentiationCells, CulturedCytokinesHumansImmunity, InnateInflammation MediatorsInsulin ResistanceInterferon-gammaInterleukin-12LymphocytesMacrophagesMiceMice, Inbred C57BLMice, TransgenicObesitySTAT4 Transcription FactorT-Box Domain ProteinsConceptsNatural killerInsulin resistanceInnate lymphoid cell functionLocal proinflammatory cytokine productionObesity-Associated Insulin ResistanceNon-barrier tissuesObesity-related pathologiesProinflammatory cytokine productionImmature NK cellsProinflammatory macrophage polarizationGroup 1 ILCsIL-12 receptorLymphoid cell functionAdipose tissue depotsTranscription factor NFIL3Parabiotic miceNK cellsCytokine productionTissue residencyT-betMacrophage polarizationReporter miceTissue depotsMetabolic diseasesEpithelial barrierAtg5 Is Essential for the Development and Survival of Innate Lymphocytes
O’Sullivan T, Geary C, Weizman O, Geiger T, Rapp M, Dorn G, Overholtzer M, Sun J. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Reports 2016, 15: 1910-1919. PMID: 27210760, PMCID: PMC4889506, DOI: 10.1016/j.celrep.2016.04.082.Peer-Reviewed Original ResearchConceptsInnate lymphocytesHomeostatic proliferationMature natural killer (NK) cellsInnate lymphoid cell developmentNatural killer cellsCell-intrinsic apoptosisLymphoreplete miceLymphoid cell developmentLymphocyte numbersKiller cellsMetformin treatmentLymphopenic hostsLymphocyte precursorsGroup 1Induction of autophagyLymphocyte survivalILC developmentInducible ablationLymphocytesLymphocyte developmentSurvivalCell developmentAutophagyATG5Cellular survival mechanism