2023
Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity
Weizman O, Luyten S, Krykbaeva I, Song E, Mao T, Bosenberg M, Iwasaki A. Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity. The Journal Of Immunology 2023, 210: 1146-1155. PMID: 36881866, PMCID: PMC10067787, DOI: 10.4049/jimmunol.2200697.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesDendritic CellsImmunity, InnateKiller Cells, NaturalMiceSignal TransductionConceptsType 2 dendritic cellsMetastatic burdenImmune circuitsDendritic cellsConventional type 2 dendritic cellsSyngeneic murine melanomaNK cell compartmentImmune cell responsesColon cancer modelEarly metastatic seedingMetastatic controlTranscription factor IRF3DC populationsNK cellsProinflammatory cytokinesNucleic acid sensingPrimary tumorEffector responsesMetastatic spreadDisease outcomeIntracardiac injectionT cellsInitial immunityTissue-specific ablationCancer modelIL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
Clark J, Weizman O, Aldridge D, Shallberg L, Eberhard J, Lanzar Z, Wasche D, Huck J, Zhou T, Ring A, Hunter C. IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Cell Reports 2023, 42: 112147. PMID: 36827187, PMCID: PMC10131179, DOI: 10.1016/j.celrep.2023.112147.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansImmunity, InnateInterleukin-12Interleukin-18Killer Cells, NaturalToxoplasmaToxoplasmosis, AnimalConceptsInnate lymphoid cellsIL-18IL-18BPNatural killerToxoplasma gondiiIL-18 binding proteinEndogenous IL-18Exogenous IL-18Cell-mediated pathologyPathological immune responsesProduction of IFNAnti-pathogen responsesCell productionInterleukin-18Immune pathologyImmune responseLymphoid cellsCell responsesInnate resistanceCD4IFNGondiiInfectionPathologyLimited roleInfection induces tissue-resident memory NK cells that safeguard tissue health
Schuster I, Sng X, Lau C, Powell D, Weizman O, Fleming P, Neate G, Voigt V, Sheppard S, Maraskovsky A, Daly S, Koyama M, Hill G, Turner S, O'Sullivan T, Sun J, Andoniou C, Degli-Esposti M. Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity 2023, 56: 531-546.e6. PMID: 36773607, PMCID: PMC10360410, DOI: 10.1016/j.immuni.2023.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCytomegalovirus InfectionsHumansImmunity, InnateKiller Cells, NaturalMiceMuromegalovirusT-LymphocytesConceptsNK cellsTissue healthAdaptive-like featuresMemory NK cellsNatural killer cellsMurine cytomegalovirus infectionNon-lymphoid tissuesTissue-resident populationsCytomegalovirus infectionInnate cellsInnate lymphocytesKiller cellsAutoimmune diseasesTissue residencyImmune responseAdaptive immunityImmune equilibriumCardinal featuresSalivary glandsAdditional strategiesHealthCellsTissueCD4Response
2019
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, Aguilar O, Leslie C, Carlyle J, Sun J, O’Sullivan T. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature Immunology 2019, 20: 1004-1011. PMID: 31263280, PMCID: PMC6697419, DOI: 10.1038/s41590-019-0430-1.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsTissue-resident innate lymphoid cellsType 1 innate lymphoid cellsMouse cytomegalovirusMemory lymphocyte responsesResolution of infectionTissue-resident sentinelsPathogen-derived antigensEarly host protectionLymphocyte responsesBystander activationProinflammatory cytokinesHeterologous infectionsMCMV infectionEffector responsesSecondary challengeHost protectionLymphoid cellsMemory responsesInfectionInitial sitePresent studyPhenotypic changesResponseILC1s
2018
Epigenetic control of innate and adaptive immune memory
Lau C, Adams N, Geary C, Weizman O, Rapp M, Pritykin Y, Leslie C, Sun J. Epigenetic control of innate and adaptive immune memory. Nature Immunology 2018, 19: 963-972. PMID: 30082830, PMCID: PMC6225771, DOI: 10.1038/s41590-018-0176-1.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCD8-Positive T-LymphocytesCells, CulturedChromatinClonal Selection, Antigen-MediatedEpigenesis, GeneticGene Expression ProfilingHerpesviridae InfectionsImmunity, InnateImmunologic MemoryKiller Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutMuromegalovirusSTAT1 Transcription FactorSTAT4 Transcription FactorConceptsMammalian adaptive immune responseNK cellsDistinct epigenetic signaturesChromatin profilingAdaptive immune memoryAdaptive traitsEpigenetic controlTranscriptional statesNatural killer cellsT cell responsesAdaptive immune responsesEpigenetic modificationsEpigenetic signaturesTranscription factorsEpigenetic profilesInnate immune systemAccessibility stateRegulatory programsCanonical CD8Killer cellsImmunological memorySame infectionLymphocyte memoryT cellsImmune response
2017
ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
Weizman O, Adams N, Schuster I, Krishna C, Pritykin Y, Lau C, Degli-Esposti M, Leslie C, Sun J, O’Sullivan T. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell 2017, 171: 795-808.e12. PMID: 29056343, PMCID: PMC5687850, DOI: 10.1016/j.cell.2017.09.052.Peer-Reviewed Original ResearchConceptsImmune cellsViral infectionType 1 innate lymphoid cellsInitial antiviral responseInnate lymphoid cellsTissue-resident lymphocytesConventional dendritic cellsInnate immune cellsSite of infectionEarly antiviral immunityEarly host protectionViral burdenDendritic cellsViral loadProinflammatory cytokinesPrimary infectionAntiviral immunityHost protectionLymphoid cellsHost immunityInitial infectionAntiviral responseInfectionSTAT4-dependent mannerInitial site
2016
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
O’Sullivan T, Rapp M, Fan X, Weizman O, Bhardwaj P, Adams N, Walzer T, Dannenberg A, Sun J. Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity 2016, 45: 428-441. PMID: 27496734, PMCID: PMC5004886, DOI: 10.1016/j.immuni.2016.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBasic-Leucine Zipper Transcription FactorsCell DifferentiationCells, CulturedCytokinesHumansImmunity, InnateInflammation MediatorsInsulin ResistanceInterferon-gammaInterleukin-12LymphocytesMacrophagesMiceMice, Inbred C57BLMice, TransgenicObesitySTAT4 Transcription FactorT-Box Domain ProteinsConceptsNatural killerInsulin resistanceInnate lymphoid cell functionLocal proinflammatory cytokine productionObesity-Associated Insulin ResistanceNon-barrier tissuesObesity-related pathologiesProinflammatory cytokine productionImmature NK cellsProinflammatory macrophage polarizationGroup 1 ILCsIL-12 receptorLymphoid cell functionAdipose tissue depotsTranscription factor NFIL3Parabiotic miceNK cellsCytokine productionTissue residencyT-betMacrophage polarizationReporter miceTissue depotsMetabolic diseasesEpithelial barrierAtg5 Is Essential for the Development and Survival of Innate Lymphocytes
O’Sullivan T, Geary C, Weizman O, Geiger T, Rapp M, Dorn G, Overholtzer M, Sun J. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Reports 2016, 15: 1910-1919. PMID: 27210760, PMCID: PMC4889506, DOI: 10.1016/j.celrep.2016.04.082.Peer-Reviewed Original ResearchConceptsInnate lymphocytesHomeostatic proliferationMature natural killer (NK) cellsInnate lymphoid cell developmentNatural killer cellsCell-intrinsic apoptosisLymphoreplete miceLymphoid cell developmentLymphocyte numbersKiller cellsMetformin treatmentLymphopenic hostsLymphocyte precursorsGroup 1Induction of autophagyLymphocyte survivalILC developmentInducible ablationLymphocytesLymphocyte developmentSurvivalCell developmentAutophagyATG5Cellular survival mechanism