Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses
Rapp M, Lau C, Adams N, Weizman O, O'Sullivan T, Geary C, Sun J. Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Science Immunology 2017, 2 PMID: 29222089, PMCID: PMC6265048, DOI: 10.1126/sciimmunol.aan3796.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitCore Binding Factor beta SubunitKiller Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutSTAT4 Transcription FactorConceptsRunx transcription factorsTranscription factorsGene locusNK cellsTranscription factor signal transducerCell cycle programCore-binding factor βHistone mark H3K4me3Epigenetic controlAdaptive natural killer cell responsesChromatin immunoprecipitationEpigenetic modificationsClonal expansionNatural killer cell responsesSignal transducerPromoter regionMemory NK cellsNatural killer cellsNK cell activationTranscription 4Cycle programSpecific ablationInnate lymphocytesKiller cellsFactor β