Epigenetic control of innate and adaptive immune memory
Lau C, Adams N, Geary C, Weizman O, Rapp M, Pritykin Y, Leslie C, Sun J. Epigenetic control of innate and adaptive immune memory. Nature Immunology 2018, 19: 963-972. PMID: 30082830, PMCID: PMC6225771, DOI: 10.1038/s41590-018-0176-1.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCD8-Positive T-LymphocytesCells, CulturedChromatinClonal Selection, Antigen-MediatedEpigenesis, GeneticGene Expression ProfilingHerpesviridae InfectionsImmunity, InnateImmunologic MemoryKiller Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutMuromegalovirusSTAT1 Transcription FactorSTAT4 Transcription FactorConceptsMammalian adaptive immune responseNK cellsDistinct epigenetic signaturesChromatin profilingAdaptive immune memoryAdaptive traitsEpigenetic controlTranscriptional statesNatural killer cellsT cell responsesAdaptive immune responsesEpigenetic modificationsEpigenetic signaturesTranscription factorsEpigenetic profilesInnate immune systemAccessibility stateRegulatory programsCanonical CD8Killer cellsImmunological memorySame infectionLymphocyte memoryT cellsImmune response