Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
Adams N, Lau C, Fan X, Rapp M, Geary C, Weizman O, Diaz-Salazar C, Sun J. Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Immunity 2018, 48: 1172-1182.e6. PMID: 29858012, PMCID: PMC6233715, DOI: 10.1016/j.immuni.2018.04.018.Peer-Reviewed Original ResearchConceptsNK cellsViral infectionAdaptive natural killer cell responsesVirus-specific NK cellsNatural killer cell responsesNK cell deficiencyNK cell functionNatural killer cellsNK cell proliferationSevere viral infectionsMouse cytomegalovirus (MCMV) infectionIRF8 mutationsTranscription factor STAT4Cytomegalovirus infectionInnate lymphocytesKiller cellsViral exposureCell deficiencyAdaptive immunityAntiviral immunityTranscription factor IRF8Cell responsesBiallelic mutationsViral susceptibilityInfection