Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge
Johnson L, Weizman O, Rapp M, Way S, Sun J. Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge. Cell Reports 2016, 17: 636-644. PMID: 27732841, PMCID: PMC5503750, DOI: 10.1016/j.celrep.2016.09.019.Peer-Reviewed Original ResearchConceptsRecall responsesClonal expansionDifferent dendritic cellsInnate lymphocyte responsesRobust recall responsesPrimary immune responseNaive T cellsDifferent activation requirementsHeterotypic antigensMemory CD8Dendritic cellsLymphocyte responsesNaive CD8NK cellsCell primingProtective immunityDistinct anatomical locationsPrior infectionVaccination strategiesViral challengeT cellsImmune responseCell epitopesSecondary epitopesHeterologous antigens