2023
Infection induces tissue-resident memory NK cells that safeguard tissue health
Schuster I, Sng X, Lau C, Powell D, Weizman O, Fleming P, Neate G, Voigt V, Sheppard S, Maraskovsky A, Daly S, Koyama M, Hill G, Turner S, O'Sullivan T, Sun J, Andoniou C, Degli-Esposti M. Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity 2023, 56: 531-546.e6. PMID: 36773607, PMCID: PMC10360410, DOI: 10.1016/j.immuni.2023.01.016.Peer-Reviewed Original ResearchConceptsNK cellsTissue healthAdaptive-like featuresMemory NK cellsNatural killer cellsMurine cytomegalovirus infectionNon-lymphoid tissuesTissue-resident populationsCytomegalovirus infectionInnate cellsInnate lymphocytesKiller cellsAutoimmune diseasesTissue residencyImmune responseAdaptive immunityImmune equilibriumCardinal featuresSalivary glandsAdditional strategiesHealthCellsTissueCD4Response
2019
Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells
Adams N, Geary C, Santosa E, Lumaquin D, Le Luduec J, Sottile R, van der Ploeg K, Hsu J, Whitlock B, Jackson B, Weizman O, Huse M, Hsu K, Sun J. Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity 2019, 50: 1381-1390.e5. PMID: 31103381, PMCID: PMC6614060, DOI: 10.1016/j.immuni.2019.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytomegalovirusCytomegalovirus InfectionsCytotoxicity, ImmunologicGene Expression RegulationHerpesviridae InfectionsHost-Pathogen InteractionsHumansImmunologic MemoryKiller Cells, NaturalLymphocyte ActivationMiceMice, KnockoutMuromegalovirusNK Cell Lectin-Like Receptor Subfamily AT-Cell Antigen Receptor SpecificityConceptsNatural killer cellsNK cellsKiller cellsNK cell effector functionsMemory NK cellsNK cell poolHuman NK cellsCell effector functionsHuman CMV infectionCMV infectionCytomegalovirus infectionInnate lymphocytesAdaptive immunityAntiviral immunityEffector functionsRelevant antigensPreferential expansionHigh avidityCell avidityAntigen receptorCell poolAvidityAffinity maturationInfectionImmunity
2017
Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses
Rapp M, Lau C, Adams N, Weizman O, O'Sullivan T, Geary C, Sun J. Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Science Immunology 2017, 2 PMID: 29222089, PMCID: PMC6265048, DOI: 10.1126/sciimmunol.aan3796.Peer-Reviewed Original ResearchConceptsRunx transcription factorsTranscription factorsGene locusNK cellsTranscription factor signal transducerCell cycle programCore-binding factor βHistone mark H3K4me3Epigenetic controlAdaptive natural killer cell responsesChromatin immunoprecipitationEpigenetic modificationsClonal expansionNatural killer cell responsesSignal transducerPromoter regionMemory NK cellsNatural killer cellsNK cell activationTranscription 4Cycle programSpecific ablationInnate lymphocytesKiller cellsFactor β