Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, Aguilar O, Leslie C, Carlyle J, Sun J, O’Sullivan T. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature Immunology 2019, 20: 1004-1011. PMID: 31263280, PMCID: PMC6697419, DOI: 10.1038/s41590-019-0430-1.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsTissue-resident innate lymphoid cellsType 1 innate lymphoid cellsMouse cytomegalovirusMemory lymphocyte responsesResolution of infectionTissue-resident sentinelsPathogen-derived antigensEarly host protectionLymphocyte responsesBystander activationProinflammatory cytokinesHeterologous infectionsMCMV infectionEffector responsesSecondary challengeHost protectionLymphoid cellsMemory responsesInfectionInitial sitePresent studyPhenotypic changesResponseILC1sCytomegalovirus infection drives avidity selection of natural killer cells
Adams N, Lumaquin D, Santosa E, Whitlock B, Jackson B, Le Luduec J, Sottile R, Weizman O, Huse M, Hsu K, Sun J. Cytomegalovirus infection drives avidity selection of natural killer cells. The Journal Of Immunology 2019, 202: 76.3-76.3. DOI: 10.4049/jimmunol.202.supp.76.3.Peer-Reviewed Original ResearchNK cell poolNK cellsNatural killer cellsKiller cellsImmune responseNK cell effector functionsNK cell populationHuman NK cellsIFN-γ productionCell effector functionsCell poolSecondary immune responseAntiviral immune responseHuman CMV infectionGreater receptor affinityGreater clonal expansionCMV infectionCytomegalovirus infectionInnate lymphocytesAvidity maturationInfectious challengeMCMV infectionReceptor expressionVirus infectionEffector functions