2019
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, Aguilar O, Leslie C, Carlyle J, Sun J, O’Sullivan T. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature Immunology 2019, 20: 1004-1011. PMID: 31263280, PMCID: PMC6697419, DOI: 10.1038/s41590-019-0430-1.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsTissue-resident innate lymphoid cellsType 1 innate lymphoid cellsMouse cytomegalovirusMemory lymphocyte responsesResolution of infectionTissue-resident sentinelsPathogen-derived antigensEarly host protectionLymphocyte responsesBystander activationProinflammatory cytokinesHeterologous infectionsMCMV infectionEffector responsesSecondary challengeHost protectionLymphoid cellsMemory responsesInfectionInitial sitePresent studyPhenotypic changesResponseILC1s
2016
Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge
Johnson L, Weizman O, Rapp M, Way S, Sun J. Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge. Cell Reports 2016, 17: 636-644. PMID: 27732841, PMCID: PMC5503750, DOI: 10.1016/j.celrep.2016.09.019.Peer-Reviewed Original ResearchConceptsRecall responsesClonal expansionDifferent dendritic cellsInnate lymphocyte responsesRobust recall responsesPrimary immune responseNaive T cellsDifferent activation requirementsHeterotypic antigensMemory CD8Dendritic cellsLymphocyte responsesNaive CD8NK cellsCell primingProtective immunityDistinct anatomical locationsPrior infectionVaccination strategiesViral challengeT cellsImmune responseCell epitopesSecondary epitopesHeterologous antigens