2023
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
Clark J, Weizman O, Aldridge D, Shallberg L, Eberhard J, Lanzar Z, Wasche D, Huck J, Zhou T, Ring A, Hunter C. IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Cell Reports 2023, 42: 112147. PMID: 36827187, PMCID: PMC10131179, DOI: 10.1016/j.celrep.2023.112147.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsIL-18IL-18BPNatural killerToxoplasma gondiiIL-18 binding proteinEndogenous IL-18Exogenous IL-18Cell-mediated pathologyPathological immune responsesProduction of IFNAnti-pathogen responsesCell productionInterleukin-18Immune pathologyImmune responseLymphoid cellsCell responsesInnate resistanceCD4IFNGondiiInfectionPathologyLimited role
2019
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, Aguilar O, Leslie C, Carlyle J, Sun J, O’Sullivan T. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature Immunology 2019, 20: 1004-1011. PMID: 31263280, PMCID: PMC6697419, DOI: 10.1038/s41590-019-0430-1.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsTissue-resident innate lymphoid cellsType 1 innate lymphoid cellsMouse cytomegalovirusMemory lymphocyte responsesResolution of infectionTissue-resident sentinelsPathogen-derived antigensEarly host protectionLymphocyte responsesBystander activationProinflammatory cytokinesHeterologous infectionsMCMV infectionEffector responsesSecondary challengeHost protectionLymphoid cellsMemory responsesInfectionInitial sitePresent studyPhenotypic changesResponseILC1s
2017
ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
Weizman O, Adams N, Schuster I, Krishna C, Pritykin Y, Lau C, Degli-Esposti M, Leslie C, Sun J, O’Sullivan T. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell 2017, 171: 795-808.e12. PMID: 29056343, PMCID: PMC5687850, DOI: 10.1016/j.cell.2017.09.052.Peer-Reviewed Original ResearchConceptsImmune cellsViral infectionType 1 innate lymphoid cellsInitial antiviral responseInnate lymphoid cellsTissue-resident lymphocytesConventional dendritic cellsInnate immune cellsSite of infectionEarly antiviral immunityEarly host protectionViral burdenDendritic cellsViral loadProinflammatory cytokinesPrimary infectionAntiviral immunityHost protectionLymphoid cellsHost immunityInitial infectionAntiviral responseInfectionSTAT4-dependent mannerInitial site