ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
Weizman O, Adams N, Schuster I, Krishna C, Pritykin Y, Lau C, Degli-Esposti M, Leslie C, Sun J, O’Sullivan T. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell 2017, 171: 795-808.e12. PMID: 29056343, PMCID: PMC5687850, DOI: 10.1016/j.cell.2017.09.052.Peer-Reviewed Original ResearchConceptsImmune cellsViral infectionType 1 innate lymphoid cellsInitial antiviral responseInnate lymphoid cellsTissue-resident lymphocytesConventional dendritic cellsInnate immune cellsSite of infectionEarly antiviral immunityEarly host protectionViral burdenDendritic cellsViral loadProinflammatory cytokinesPrimary infectionAntiviral immunityHost protectionLymphoid cellsHost immunityInitial infectionAntiviral responseInfectionSTAT4-dependent mannerInitial site