Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells
Adams N, Geary C, Santosa E, Lumaquin D, Le Luduec J, Sottile R, van der Ploeg K, Hsu J, Whitlock B, Jackson B, Weizman O, Huse M, Hsu K, Sun J. Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity 2019, 50: 1381-1390.e5. PMID: 31103381, PMCID: PMC6614060, DOI: 10.1016/j.immuni.2019.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytomegalovirusCytomegalovirus InfectionsCytotoxicity, ImmunologicGene Expression RegulationHerpesviridae InfectionsHost-Pathogen InteractionsHumansImmunologic MemoryKiller Cells, NaturalLymphocyte ActivationMiceMice, KnockoutMuromegalovirusNK Cell Lectin-Like Receptor Subfamily AT-Cell Antigen Receptor SpecificityConceptsNatural killer cellsNK cellsKiller cellsNK cell effector functionsMemory NK cellsNK cell poolHuman NK cellsCell effector functionsHuman CMV infectionCMV infectionCytomegalovirus infectionInnate lymphocytesAdaptive immunityAntiviral immunityEffector functionsRelevant antigensPreferential expansionHigh avidityCell avidityAntigen receptorCell poolAvidityAffinity maturationInfectionImmunityCytomegalovirus infection drives avidity selection of natural killer cells
Adams N, Lumaquin D, Santosa E, Whitlock B, Jackson B, Le Luduec J, Sottile R, Weizman O, Huse M, Hsu K, Sun J. Cytomegalovirus infection drives avidity selection of natural killer cells. The Journal Of Immunology 2019, 202: 76.3-76.3. DOI: 10.4049/jimmunol.202.supp.76.3.Peer-Reviewed Original ResearchNK cell poolNK cellsNatural killer cellsKiller cellsImmune responseNK cell effector functionsNK cell populationHuman NK cellsIFN-γ productionCell effector functionsCell poolSecondary immune responseAntiviral immune responseHuman CMV infectionGreater receptor affinityGreater clonal expansionCMV infectionCytomegalovirus infectionInnate lymphocytesAvidity maturationInfectious challengeMCMV infectionReceptor expressionVirus infectionEffector functions