2023
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
Clark J, Weizman O, Aldridge D, Shallberg L, Eberhard J, Lanzar Z, Wasche D, Huck J, Zhou T, Ring A, Hunter C. IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Cell Reports 2023, 42: 112147. PMID: 36827187, PMCID: PMC10131179, DOI: 10.1016/j.celrep.2023.112147.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsIL-18IL-18BPNatural killerToxoplasma gondiiIL-18 binding proteinEndogenous IL-18Exogenous IL-18Cell-mediated pathologyPathological immune responsesProduction of IFNAnti-pathogen responsesCell productionInterleukin-18Immune pathologyImmune responseLymphoid cellsCell responsesInnate resistanceCD4IFNGondiiInfectionPathologyLimited role
2018
Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
Adams N, Lau C, Fan X, Rapp M, Geary C, Weizman O, Diaz-Salazar C, Sun J. Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Immunity 2018, 48: 1172-1182.e6. PMID: 29858012, PMCID: PMC6233715, DOI: 10.1016/j.immuni.2018.04.018.Peer-Reviewed Original ResearchConceptsNK cellsViral infectionAdaptive natural killer cell responsesVirus-specific NK cellsNatural killer cell responsesNK cell deficiencyNK cell functionNatural killer cellsNK cell proliferationSevere viral infectionsMouse cytomegalovirus (MCMV) infectionIRF8 mutationsTranscription factor STAT4Cytomegalovirus infectionInnate lymphocytesKiller cellsViral exposureCell deficiencyAdaptive immunityAntiviral immunityTranscription factor IRF8Cell responsesBiallelic mutationsViral susceptibilityInfection