Atg5 Is Essential for the Development and Survival of Innate Lymphocytes
O’Sullivan T, Geary C, Weizman O, Geiger T, Rapp M, Dorn G, Overholtzer M, Sun J. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Reports 2016, 15: 1910-1919. PMID: 27210760, PMCID: PMC4889506, DOI: 10.1016/j.celrep.2016.04.082.Peer-Reviewed Original ResearchConceptsInnate lymphocytesHomeostatic proliferationMature natural killer (NK) cellsInnate lymphoid cell developmentNatural killer cellsCell-intrinsic apoptosisLymphoreplete miceLymphoid cell developmentLymphocyte numbersKiller cellsMetformin treatmentLymphopenic hostsLymphocyte precursorsGroup 1Induction of autophagyLymphocyte survivalILC developmentInducible ablationLymphocytesLymphocyte developmentSurvivalCell developmentAutophagyATG5Cellular survival mechanism