2022
What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Network A. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e1-e13. PMID: 34989701, PMCID: PMC8769352, DOI: 10.1097/pcc.0000000000002854.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceIll pediatric patientsIll childrenPlasma transfusionPediatric patientsPlatelet transfusionsConsensus statementSystematic reviewLos Angeles Appropriateness MethodPhysiologic triggerExpert-based statementsCritically Ill ChildrenDevelopment/UniversityExpert consensus statementCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion managementAppropriateness MethodBlood productsLaboratory testingTransfusionLibrary databasesConsensus conferenceExpert consensus
2021
Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study
Nellis ME, Vasovic LV, Goel R, Karam O. Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study. Frontiers In Pediatrics 2021, 9: 673613. PMID: 34041211, PMCID: PMC8141845, DOI: 10.3389/fped.2021.673613.Peer-Reviewed Original ResearchHemostatic blood productsECMO daysPercent of childrenBlood productsMembrane oxygenationPediatric Health Information System Database StudyPediatric Health Information System databaseHealth Information System databaseUse of TXAHospital mortality rateRetrospective observational studyU.S. children's hospitalsExtracorporeal membrane oxygenationMedian ageChildren's HospitalMedian lengthHemostatic measuresInformation System databaseObservational studyECMODatabase studyHigh riskMortality rateHemostatic agentsFactor VIIaTransfusion management for children supported by extracorporeal membrane oxygenation
Karam O, Nellis ME. Transfusion management for children supported by extracorporeal membrane oxygenation. Transfusion 2021, 61: 660-664. PMID: 33491189, DOI: 10.1111/trf.16272.Peer-Reviewed Original Research
2019
Transfusion Management in Pediatric Oncology Patients
Nellis ME, Goel R, Karam O. Transfusion Management in Pediatric Oncology Patients. Hematology/Oncology Clinics Of North America 2019, 33: 903-913. PMID: 31466612, DOI: 10.1016/j.hoc.2019.05.011.Peer-Reviewed Original ResearchConceptsPediatric oncology patientsOncology patientsBlood productsStrong evidence-based guidelinesRestrictive transfusion strategyEvidence-based guidelinesNumerous transfusionsPlasma transfusionRed blood cellsTransfusion strategyTransfusion managementPatient populationBlood cellsTransfusionPatientsMorbidity