2019
Transfusion in children with acute respiratory distress syndrome.
François T, Emeriaud G, Karam O, Tucci M. Transfusion in children with acute respiratory distress syndrome. Annals Of Translational Medicine 2019, 7: 511. PMID: 31728364, PMCID: PMC6828792, DOI: 10.21037/atm.2019.08.28.Peer-Reviewed Original ResearchAcute respiratory distress syndromeRespiratory distress syndromeSevere PARDSDistress syndromeRestrictive red blood cell transfusion strategyRed blood cell transfusion strategyLow oxygen deliveryPossible beneficial effectsProphylactic transfusionStable patientsTransfusion strategyPediatric patientsRBC transfusionHemoglobin levelsLarge trialsAppropriate indicationsPatient populationRecent guidelinesFrequent treatmentTransfusionOxygen deliveryBeneficial effectsHemostatic productsPotential deleterious impactPatientsInternational Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsOncologic diagnosisIll childrenCurrent recommendationsHematopoietic stem cell transplantationCritically Ill ChildrenExtracorporeal life supportStem cell transplantationTotal platelet countMechanical ventilationPlatelet countAppropriate indicationsCell transplantationPediatric intensivistsSubgroup analysisObservational studyPlatelet functionTransfusionParent studyTherapeutic transfusionTotal plateletsLife supportDiagnosisVulnerable populationsSignificant differences
2018
International, multicentre, observational study of fluid bolus therapy in neonates
Keir AK, Karam O, Hodyl N, Stark MJ, Liley HG, Shah PS, Stanworth SJ, Group O. International, multicentre, observational study of fluid bolus therapy in neonates. Journal Of Paediatrics And Child Health 2018, 55: 632-639. PMID: 30328174, DOI: 10.1111/jpc.14260.Peer-Reviewed Original ResearchConceptsFluid bolus therapyBolus therapyNeonatal unitHaemodynamic compromiseObservational studyFluid bolus administrationMulticentre observational studyRisk-benefit profilePooled prevalence rateWide international variationDays of ageClinical improvementFrequent indicationAppropriate indicationsFluid bolusMetabolic acidosisPoor perfusionPatient daysBolus administrationPrevalence ratesStudy daysNeonatesStudy periodTherapyRelevant studiesPlatelet Transfusion Practices in Critically Ill Children
Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsCells/LMajor bleedingProphylactic transfusionICU mortalityMinor bleedingIll childrenOverall ICU mortalityPediatric critical illnessPlatelet transfusion practicesProspective cohort studyProphylactic platelet transfusionsCohort studyCritical illnessPost transfusionAdjusted analysisPlatelet countTransfusion practiceAppropriate indicationsMedian changePlatelet doseTransfusionBleedingCells/L.Prophylaxis
2017
Factors influencing plasma transfusion practices in paediatric intensive care units around the world
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.Peer-Reviewed Original ResearchConceptsPlasma transfusion practicesPlasma transfusionTransfusion practiceCoagulation testsPediatric intensive care unitInternational pediatric studiesLocal transfusion serviceAbnormal coagulation testsIntensive care unitEfficacy of transfusionSignificant relevant factorTransfusion policyTransfusion rateCare unitAppropriate indicationsPediatric studiesFrequent treatmentTransfusionResponse rateTransfusion servicesLocal investigatorsPatientsCenter characteristicsWide variationBleeding
2016
Identifying Prognostic Criteria for Survival after Resuscitation Assisted by Extracorporeal Membrane Oxygenation
Brunner A, Dubois N, Rimensberger PC, Karam O. Identifying Prognostic Criteria for Survival after Resuscitation Assisted by Extracorporeal Membrane Oxygenation. Critical Care Research And Practice 2016, 2016: 9521091. PMID: 27006826, PMCID: PMC4781941, DOI: 10.1155/2016/9521091.Peer-Reviewed Original ResearchECMO-cardiopulmonary resuscitationExtracorporeal membrane oxygenationMembrane oxygenationNormal cognitive statusECMO initiationHospital staySpastic quadriplegiaPrognostic factorsSuccessful weaningClinical outcomesPoor outcomeAppropriate indicationsPrognostic criteriaCardiopulmonary resuscitationSurvival ratePatientsCognitive statusLower lactateOverall rateResuscitationSurvivalChildrenSurvivorsOxygenationShorter length