2020
α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference
Perez RE, Basu A, Nabit BP, Harris NA, Folkes OM, Patel S, Gilsbach R, Hein L, Winder DG. α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference. Neuropsychopharmacology 2020, 45: 1473-1481. PMID: 32074627, PMCID: PMC7360592, DOI: 10.1038/s41386-020-0641-z.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementStress-induced relapseBNST activityPlace preferenceDesigner drug (DREADD) approachEfficacy of guanfacineImpact of doseStress-induced cravingSubstance use disordersKey brain regionsRelapse rateBeneficial efficacyCPP procedureAgonist guanfacineDesigner receptorsGenetic deletion strategiesStria terminalisBed nucleusHeteroreceptorsUse disordersGuanfacineHuman studiesAnimal modelsCocaine CPPPotential treatment
2013
Antioxidant Supplementation Ameliorates Molecular Deficits in Smith-Lemli-Opitz Syndrome
Korade Z, Xu L, Harrison FE, Ahsen R, Hart SE, Folkes OM, Mirnics K, Porter NA. Antioxidant Supplementation Ameliorates Molecular Deficits in Smith-Lemli-Opitz Syndrome. Biological Psychiatry 2013, 75: 215-222. PMID: 23896203, PMCID: PMC3874268, DOI: 10.1016/j.biopsych.2013.06.013.Peer-Reviewed Original ResearchConceptsVitamin EPregnant female miceTransgenic mouse modelSLOS patientsPatient cell culturesSmith-LemliOpitz syndromeQuantitative polymerase chain reactionAntioxidant mixturePolymerase chain reactionFemale miceAntioxidant supplementationMouse modelRodent modelsGlial culturesAntioxidant treatmentVitamin AActive oxysterolsMolecular deficitsCoenzyme Q10Liver tissueWestern blotInborn errorsMaternal feedingLiquid chromatography-tandem mass spectrometry