Student Research Award 1998: Cytokine‐mediated bone resorption is cytochrome P‐450 dependent
Young N, Chole R. Student Research Award 1998: Cytokine‐mediated bone resorption is cytochrome P‐450 dependent. Otolaryngology 1999, 121: 708-712. PMID: 10580224, DOI: 10.1053/hn.1999.v121.a101034.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone ResorptionCimetidineClotrimazoleCytochrome P-450 Enzyme SystemDose-Response Relationship, DrugEnzyme InhibitorsFemaleMiceMice, Inbred StrainsNitric OxideConceptsCytokine-induced bone resorptionBone resorptionNitric oxideChronic otitis mediaCytochrome PBone lossOtitis mediaTumor necrosisInterleukin-1betaNO synthaseL-arginineBone remodelingResorptionPowerful inducerSelective inhibitorCytokinesPossible roleNOSConcomitant reductionBoneCellular eventsInhibitorsAlternative pathwayEssential cofactorMorbidity