2023
Hydroxyapatite Use in Repair of Lateral Skull Base CSF Leaks Via Transmastoid Approach: When Does It Work?
Shah R, Kveton J, Schwartz N. Hydroxyapatite Use in Repair of Lateral Skull Base CSF Leaks Via Transmastoid Approach: When Does It Work? Otology & Neurotology 2023, 44: 804-808. PMID: 37550871, DOI: 10.1097/mao.0000000000003973.Peer-Reviewed Original ResearchConceptsCSF leak repairTransmastoid approachTertiary level care hospitalSkull Base Cerebrospinal Fluid LeaksLeak repairHydroxyapatite cementPrior smoking historyTrans-mastoid approachPatients 18 yearsRetrospective cohort studyRecurrence of symptomsVP shunt placementPatient demographic factorsBenign intracranial hypertensionSpontaneous CSF leaksCerebrospinal fluid leakFailure rateSkull base repairAverage defect sizeRepair cohortRecurrent symptomsAdjuvant treatmentFormer smokersSmoking historyCohort study
2021
Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks
Schwartz N, Brown KD, Sasaki-Adams D, Morgan SA, Zanation AM, Thorp BD, O’Connell B. Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks. Otology & Neurotology 2021, 42: e624-e628. PMID: 33416298, DOI: 10.1097/mao.0000000000003048.Peer-Reviewed Original ResearchConceptsSpontaneous CSF leaksSpontaneous cerebrospinal fluid leaksElevated intracranial pressureCerebrospinal fluid leakCSF leakSurgical repairSurgical outcomesIntracranial pressureFluid leakSkull basePatients 18 yearsPercent of patientsTertiary referral centerRetrospective case seriesBody mass indexCSF leak repairOverall success rateCSF leak patientsAfrican AmericansSkull base defectsLeak patientsReferral centerCase seriesClinical presentationMass index
2020
MRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection
Schwartz N, Rooth MA, Dillon MT, O'Connell BP, Dedmon MM, Huang BY, Brown KD. MRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection. American Journal Of Otolaryngology 2020, 41: 102518. PMID: 32451290, DOI: 10.1016/j.amjoto.2020.102518.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCochlear ImplantationCochlear NerveCranial Nerve NeoplasmsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMonitoring, PhysiologicNeuroma, AcousticOrgan Sparing TreatmentsPostoperative PeriodRetrospective StudiesVestibulocochlear NerveVestibulocochlear Nerve DiseasesConceptsInternal auditory canalConcurrent cochlear implantationVestibular schwannoma resectionIpsilateral internal auditory canalCerebellopontine angleSchwannoma resectionCochlear nerveCochlear implantationHead MRITranslabyrinthine vestibular schwannoma resectionCochlear implant magnetResidual tumor growthCI recipientsMagnetic resonance imaging (MRI) monitoringTranslabyrinthine excisionImplant magnetMRI surveillanceRetrospective reviewVS tumorsTumor recurrenceAuditory canalSerial monitoringCI magnetExcellent visualizationTumor growthLoss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma
Verma A, Schwartz N, Cohen DJ, Patel V, Nageris B, Bachar G, Boyan BD, Schwartz Z. Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma. Scientific Reports 2020, 10: 4227. PMID: 32144339, PMCID: PMC7060328, DOI: 10.1038/s41598-020-60675-2.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaERβ expressionCell carcinomaLaryngeal squamous cell carcinomaEstrogen receptor-dependent mechanismHigh ESR1 expressionClinical cancer stageCancer Genome AtlasImproved survivalTumor burdenPathological stageResponsive cancersCancer stageERα36 expressionHistopathological markersEstrogen receptorXenograft tumorsESR1 expressionTumor aggressionEpithelial samplesLSCCDependent mechanismGenome AtlasERα66Carcinoma
2019
Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer
Verma A, Schwartz N, Cohen DJ, Boyan BD, Schwartz Z. Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. Steroids 2019, 152: 108498. PMID: 31539535, DOI: 10.1016/j.steroids.2019.108498.Peer-Reviewed Original ResearchConceptsSex hormone receptorsEstrogen receptorBreast cancerHormone receptorsCanonical estrogen receptorsAnti-estrogen therapyLoss of ERαSquamous cell carcinomaEstrogen receptor αHormone therapyPrognostic valueCell carcinomaPrognostic indicatorLaryngeal cancerPrognostic markerSex hormonesLSCC tumorsEstrogen signalingReceptor αTumor growthPathogenic markersEnhanced aggressionImportant modulatorERαCancer24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo
Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, Schwartz Z. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica Et Biophysica Acta (BBA) - General Subjects 2019, 1863: 1498-1512. PMID: 31125679, DOI: 10.1016/j.bbagen.2019.05.013.Peer-Reviewed Original ResearchConceptsEstrogen receptorMCF7 tumor growthBreast cancer patientsBreast cancer cell survivalBreast cancer xenograftsNarrow therapeutic windowMammary fat padDose-dependent increasePre-clinical studiesNull female miceMarker of invasionAnti-proliferative effectsBreast cancer cellsCell survivalCancer cell survivalTumor burdenAnti-tumorigenic propertiesVitamin DCancer patientsCancer xenograftsFemale miceHigh serumBreast cancerDihydroxyvitamin D3Therapeutic window
2015
Combined approach sialendoscopy for management of submandibular gland sialolithiasis
Schwartz N, Hazkani I, Goshen S. Combined approach sialendoscopy for management of submandibular gland sialolithiasis. American Journal Of Otolaryngology 2015, 36: 632-635. PMID: 26052045, DOI: 10.1016/j.amjoto.2015.04.001.Peer-Reviewed Original ResearchConceptsSubmandibular glandGland preservation ratePost-operative courseSuccess rateSalivary gland diseaseSubmandibular gland sialolithiasisTreatment of sialolithiasisSteroid irrigationLow morbidityIntraoperative findingsInstitution experienceRetrospective studyLocal anesthesiaSignificant complicationsHigh success rateClinical dataObstructive sialadenitisStone removalGland diseaseInvasive techniquesPreservation rateIntraoral incisionSialendoscopySialolithiasisGland
2013
Role of ERα36 in membrane-associated signaling by estrogen
Chaudhri RA, Schwartz N, Elbaradie K, Schwartz Z, Boyan BD. Role of ERα36 in membrane-associated signaling by estrogen. Steroids 2013, 81: 74-80. PMID: 24252378, DOI: 10.1016/j.steroids.2013.10.020.Peer-Reviewed Original ResearchConceptsCell typesPlasma membraneAlternative splicing variantsRole of ERα36Non-genomic responsesDifferent cell typesMembrane-associated receptorsCancer cell typesPhosphorylation cascadeTranscription factorsProtein kinaseCellular developmentGene transcriptionApoptotic signalingSplicing variantsCellular responsesNon-classical receptorsNon-classical mechanismNuclear receptorsSimilar pathwaysCell proliferationSteroid hormonesNormal cellsEstrogen receptor αTraditional receptors17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36
Schwartz N, Chaudhri RA, Hadadi A, Schwartz Z, Boyan BD. 17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36. Discover Oncology 2013, 5: 22-32. PMID: 24081562, PMCID: PMC3947116, DOI: 10.1007/s12672-013-0161-y.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCarcinogenesisCarcinomaCell ProliferationCell SurvivalDrug Resistance, NeoplasmEstradiolEstrogen Receptor alphaFemaleHeLa CellsHumansLaryngeal NeoplasmsLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMolecular Targeted TherapyNeoplasm StagingNeovascularization, PathologicPhospholipase DProtein IsoformsProtein Kinase CVascular Endothelial Growth Factor AConceptsLaryngeal cancerMembrane associated estrogen receptorsLymph node metastasisRole of E2Estrogen receptor alphaLaryngeal carcinoma cell lineSecondary sex organsChemotherapy-induced apoptosisAntiestrogen therapyNode metastasisCarcinoma cell linesLaryngeal tumorsEstrogen receptorReceptor alphaERα36Metastatic factorsSimilar associationCompelling evidenceCytoplasmic receptorsCancerTumor samplesAntiapoptotic effectNovel drugsClinical analysisE2 responsivenessThyroid Surgery in the Elderly
Schwartz N, Shpitzer T, Feinmesser R, Robenshtok E, Bachar G. Thyroid Surgery in the Elderly. Gerontology 2013, 59: 401-407. PMID: 23988591, DOI: 10.1159/000351197.Peer-Reviewed Original ResearchConceptsOlder patientsThyroid diseaseIndividual risk-benefit analysisOlder groupPrevalence of comorbiditiesRetrospective cohort studyExtent of surgeryTertiary medical centerAdvanced disease stageBetween-group differencesRisk-benefit analysisBasis of ageMore comorbiditiesAdvanced diseasePostoperative complicationsTotal thyroidectomyCohort studyElderly patientsYounger patientsMedical chartsDistant metastasisHistologic subtypeSurgical managementOperative managementRecurrence rate
2012
Correlation between Eosinophil Count and Methacholine Challenge Test in Asymptomatic Subjects
Schwartz N, Grossman A, Levy Y, Schwarz Y. Correlation between Eosinophil Count and Methacholine Challenge Test in Asymptomatic Subjects. Journal Of Asthma 2012, 49: 336-341. PMID: 22715867, DOI: 10.3109/02770903.2012.672613.Peer-Reviewed Original ResearchConceptsMethacholine challenge testNegative methacholine testMethacholine testAirway hyperresponsivenessEosinophil countAsymptomatic subjectsChallenge testSeverity of AHRPositive methacholine challenge testTotal white blood cellsPositive methacholine testPeripheral blood eosinophiliaDiagnosis of asthmaAbsolute eosinophil countTotal eosinophil countFirst-degree relativesWhite blood cellsAsthmatic activityBlood eosinophiliaAbnormal spirometryNeutrophil countMethacholine concentrationPeripheral bloodMedical CenterBlood cells
2007
Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS
Schwartz N, Shoenfeld Y, Barzilai O, Cervera R, Font J, Blank M, Yacobi S, Patlas N, Cohen A, Mevorach D, Ornoy A. Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS. Lupus 2007, 16: 110-120. PMID: 17402367, DOI: 10.1177/0961203306075741.Peer-Reviewed Original ResearchConceptsPrimary anti-phospholipid syndromeAnti-phospholipid antibodiesRecurrent pregnancy lossSystemic lupus erythematosusPlacental damagePregnancy lossBetahCG levelsPlacental growthAnti-phospholipid syndromeHuman placental explantsAnti-La antibodiesDifferent antibodiesAntiphospholipid antibodiesAnti-RoThromboembolic eventsLupus erythematosusAutoimmune diseasesPlacental explantsPredictive markerProgesterone secretionHCG secretionSensitive markerHigh titersTrophoblastic apoptosisAntibodies