2020
Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma
Verma A, Schwartz N, Cohen DJ, Patel V, Nageris B, Bachar G, Boyan BD, Schwartz Z. Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma. Scientific Reports 2020, 10: 4227. PMID: 32144339, PMCID: PMC7060328, DOI: 10.1038/s41598-020-60675-2.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaERβ expressionCell carcinomaLaryngeal squamous cell carcinomaEstrogen receptor-dependent mechanismHigh ESR1 expressionClinical cancer stageCancer Genome AtlasImproved survivalTumor burdenPathological stageResponsive cancersCancer stageERα36 expressionHistopathological markersEstrogen receptorXenograft tumorsESR1 expressionTumor aggressionEpithelial samplesLSCCDependent mechanismGenome AtlasERα66Carcinoma
2019
24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo
Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, Schwartz Z. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica Et Biophysica Acta (BBA) - General Subjects 2019, 1863: 1498-1512. PMID: 31125679, DOI: 10.1016/j.bbagen.2019.05.013.Peer-Reviewed Original ResearchConceptsEstrogen receptorMCF7 tumor growthBreast cancer patientsBreast cancer cell survivalBreast cancer xenograftsNarrow therapeutic windowMammary fat padDose-dependent increasePre-clinical studiesNull female miceMarker of invasionAnti-proliferative effectsBreast cancer cellsCell survivalCancer cell survivalTumor burdenAnti-tumorigenic propertiesVitamin DCancer patientsCancer xenograftsFemale miceHigh serumBreast cancerDihydroxyvitamin D3Therapeutic window
2017
Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes
Schwartz N, Verma A, Muktipaty C, Bivens C, Schwartz Z, Boyan BD. Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes. Steroids 2017, 142: 34-42. PMID: 29274403, DOI: 10.1016/j.steroids.2017.11.012.Peer-Reviewed Original ResearchConceptsLaryngeal cancerReceptor profileCancer cellsLaryngeal cancer patientsAnti-apoptotic effectsSteroid hormone receptorsClassical nuclear receptorsCancer cell linesClinical outcomesAnti-apoptotic potentialCancer patientsLaryngeal tumorsTreatment modalitiesSex hormonesClinical characterizationIndividual patientsEstrogen responsivenessHormone responsivenessDifferent cancer cellsCancerDifferent cancer cell linesHormone receptorsAdverse effectsReceptorsMembrane ER
2013
Role of ERα36 in membrane-associated signaling by estrogen
Chaudhri RA, Schwartz N, Elbaradie K, Schwartz Z, Boyan BD. Role of ERα36 in membrane-associated signaling by estrogen. Steroids 2013, 81: 74-80. PMID: 24252378, DOI: 10.1016/j.steroids.2013.10.020.Peer-Reviewed Original ResearchConceptsCell typesPlasma membraneAlternative splicing variantsRole of ERα36Non-genomic responsesDifferent cell typesMembrane-associated receptorsCancer cell typesPhosphorylation cascadeTranscription factorsProtein kinaseCellular developmentGene transcriptionApoptotic signalingSplicing variantsCellular responsesNon-classical receptorsNon-classical mechanismNuclear receptorsSimilar pathwaysCell proliferationSteroid hormonesNormal cellsEstrogen receptor αTraditional receptors17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36
Schwartz N, Chaudhri RA, Hadadi A, Schwartz Z, Boyan BD. 17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36. Discover Oncology 2013, 5: 22-32. PMID: 24081562, PMCID: PMC3947116, DOI: 10.1007/s12672-013-0161-y.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCarcinogenesisCarcinomaCell ProliferationCell SurvivalDrug Resistance, NeoplasmEstradiolEstrogen Receptor alphaFemaleHeLa CellsHumansLaryngeal NeoplasmsLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMolecular Targeted TherapyNeoplasm StagingNeovascularization, PathologicPhospholipase DProtein IsoformsProtein Kinase CVascular Endothelial Growth Factor AConceptsLaryngeal cancerMembrane associated estrogen receptorsLymph node metastasisRole of E2Estrogen receptor alphaLaryngeal carcinoma cell lineSecondary sex organsChemotherapy-induced apoptosisAntiestrogen therapyNode metastasisCarcinoma cell linesLaryngeal tumorsEstrogen receptorReceptor alphaERα36Metastatic factorsSimilar associationCompelling evidenceCytoplasmic receptorsCancerTumor samplesAntiapoptotic effectNovel drugsClinical analysisE2 responsiveness