2020
Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma
Verma A, Schwartz N, Cohen DJ, Patel V, Nageris B, Bachar G, Boyan BD, Schwartz Z. Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma. Scientific Reports 2020, 10: 4227. PMID: 32144339, PMCID: PMC7060328, DOI: 10.1038/s41598-020-60675-2.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaERβ expressionCell carcinomaLaryngeal squamous cell carcinomaEstrogen receptor-dependent mechanismHigh ESR1 expressionClinical cancer stageCancer Genome AtlasImproved survivalTumor burdenPathological stageResponsive cancersCancer stageERα36 expressionHistopathological markersEstrogen receptorXenograft tumorsESR1 expressionTumor aggressionEpithelial samplesLSCCDependent mechanismGenome AtlasERα66Carcinoma
2019
24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo
Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, Schwartz Z. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica Et Biophysica Acta (BBA) - General Subjects 2019, 1863: 1498-1512. PMID: 31125679, DOI: 10.1016/j.bbagen.2019.05.013.Peer-Reviewed Original ResearchConceptsEstrogen receptorMCF7 tumor growthBreast cancer patientsBreast cancer cell survivalBreast cancer xenograftsNarrow therapeutic windowMammary fat padDose-dependent increasePre-clinical studiesNull female miceMarker of invasionAnti-proliferative effectsBreast cancer cellsCell survivalCancer cell survivalTumor burdenAnti-tumorigenic propertiesVitamin DCancer patientsCancer xenograftsFemale miceHigh serumBreast cancerDihydroxyvitamin D3Therapeutic window