2024
Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization
Zhang Z, Pu Y, Yu L, Bai H, Duan W, Liu X, Nie X, Wen Z, Zheng L, Hu X, Leng X, Pan Y, Petersen N, Liu L. Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization. Journal Of The American Heart Association 2024, 13: e033633. PMID: 38533955, PMCID: PMC11179781, DOI: 10.1161/jaha.123.033633.Peer-Reviewed Original ResearchConceptsBlood pressure targetsBlood pressureAutoregulatory limitsWorse outcomesAssociated with symptomatic intracranial hemorrhageAssociated with unfavorable clinical outcomesPressure targetsAssociated with worse outcomesAssociated with poor outcomesSignificant infarction growthSymptomatic intracranial hemorrhageUnfavorable clinical outcomeLarge vessel occlusion strokeAcute ischemic strokeMean velocity indexIntracranial hemorrhageBP management strategiesNeurological deteriorationClinical outcomesInfarct growthPoor outcomeEndovascular thrombectomyOcclusion strokeRecanalizationIschemic stroke
2023
Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes
Dhar R, Kumar A, Chen Y, Begunova Y, Olexa M, Prasad A, Carey G, Gonzalez I, Bhatia K, Hamed M, Heitsch L, Mainali S, Petersen N, Lee J. Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes. Journal Of Neuroimaging 2023, 33: 606-616. PMID: 37095592, PMCID: PMC10524672, DOI: 10.1111/jon.13109.Peer-Reviewed Original ResearchConceptsLarge vessel occlusion strokeMidline shiftCSF ratioMalignant edemaCerebral edemaOcclusion strokeCerebrospinal fluidAlberta Stroke Program Early CT ScoreCSF volumeTissue plasminogen activator treatmentHealth Stroke ScalePlasminogen activator treatmentRoutine CT scansNet water uptakeDecompressive surgeryInfarct volumeStroke ScaleOsmotic therapyBaseline CTCT scoreHemispheric volumeRoutine CTSerial CTContralateral regionsCT scan
2022
Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy
Prasad A, Kobsa J, Kodali S, Bartolome D, Begunova L, Quispe-Orozco D, Farooqui M, Zevallos C, Ortega-Gutiérrez S, Anadani M, Almallouhi E, Spiotta A, Giles J, Keyrouz S, Kim J, Maier I, Liman J, Psychogios M, Riou-Comte N, Richard S, Gory B, Wolfe S, Brown P, Fargen K, Mistry E, Fakhri H, Mistry A, Wong K, Nascimento F, Kan P, de Havenon A, Sheth K, Petersen N. Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy. European Stroke Journal 2022, 7: 365-375. PMID: 36478756, PMCID: PMC9720854, DOI: 10.1177/23969873221106907.Peer-Reviewed Original ResearchBlood pressure variabilitySystolic blood pressure variabilityHigh systolic blood pressure variabilityEndovascular thrombectomyFunctional outcomePressure variabilityHigh blood pressure variabilityLower blood pressure variabilityAcute ischemic stroke patientsLarge vessel occlusion strokePoor discharge outcomeIschemic stroke patientsWorse functional outcomePoor functional outcomeBlood pressure dataHigh trajectory groupGroup-based trajectory modelingHemorrhagic transformationNeurologic outcomeDischarge outcomesSBP trajectoriesStroke patientsOcclusion strokePoor outcomeRelevant confoundersStroke Severity and Early Ischemic Changes Predict Infarct Growth Rate and Clinical Outcomes in Patients With Large‐Vessel Occlusion
Quispe‐Orozco D, Sequeiros J, Farooqui M, Zevallos C, Mendez‐Ruiz A, Dajles A, Kobsa J, Prasad A, Petersen N, Ortega‐Gutierrez S. Stroke Severity and Early Ischemic Changes Predict Infarct Growth Rate and Clinical Outcomes in Patients With Large‐Vessel Occlusion. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000182.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreHealth Stroke Scale scoreStroke Scale scoreEarly ischemic changesFast progressorsScale scoreSuccessful reperfusionStroke severityEndovascular therapyIschemic changesClinical outcomesNational InstituteAnterior circulation large vessel occlusion strokeRetrospective cohort observational studyLarge vessel occlusion strokeInfarct growth ratesComprehensive stroke centerHealth Stroke ScaleCohort observational studyFinal infarct volumeLarge vessel occlusionMultivariate logistic regressionIschemic stroke progressionYouden's J indexInfarct progression
2021
Prehospital Blood Pressure Reductions Are Associated with Neurologic Worsening in Patients With Large-vessel Occlusion Stroke (2844)
Kobsa J, Prasad A, Soto A, Kodali S, Nguyen C, Peshwe K, Orozco D, Farooqui M, Zevallos C, Sansing L, Schindler J, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Prehospital Blood Pressure Reductions Are Associated with Neurologic Worsening in Patients With Large-vessel Occlusion Stroke (2844). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2844.Peer-Reviewed Original ResearchLarge vessel occlusion strokeBlood pressure reductionNeurologic worseningOcclusion strokePressure reductionPatientsStrokeWorsening