2013
Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice
Sorensen M, Grossmann S, Roesinger M, Gresko N, Todkar A, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J. Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney International 2013, 83: 811-824. PMID: 23447069, DOI: 10.1038/ki.2013.14.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAldosteroneAnimalsBiological TransportCytochrome P-450 CYP11B2Epithelial Sodium ChannelsFemaleKidneyMaleMiceMice, Inbred C57BLMice, KnockoutNatriuresisPhosphorylationPotassium, DietaryReceptors, DrugSolute Carrier Family 12, Member 3SymportersTime FactorsWater-Electrolyte BalanceConceptsNaCl cotransporterPotassium loadAcute oral potassium loadOral potassium loadRenal potassium excretionUrinary sodium lossPlasma potassium concentrationDietary potassium loadSodium chloride cotransporterRenal sodium chloride cotransporterPlasma AldoAldosterone levelsSodium excretionNatriuretic effectPotassium excretionUrinary potassiumPotassium intakeEpithelial sodium channelGastric gavagePlasma potassiumSpot urineDistal nephronIntraluminal sodiumFunctional changesChloride cotransporter
2010
In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule
Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier B, Loffing J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American Journal Of Physiology. Renal Physiology 2010, 299: f1473-f1485. PMID: 20861076, DOI: 10.1152/ajprenal.00437.2010.Peer-Reviewed Original ResearchConceptsAldosterone-sensitive distal nephronThick ascending limbGlucocorticoid receptorLate distal convoluted tubuleLow-dose corticosterone replacementSegment-specific cellsNuclear translocationDietary NaCl loadingDistal convoluted tubuleKidneys of ratsDehydrogenase type 2Proximal tubule cellsAldosterone replacementMineralocorticoid selectivityPlasma aldosteroneCorticosteroid effectsCorticosterone replacementControl ratsDistal tubulesDistal nephronConvoluted tubulesNaCl loadingCorticosterone levelsAscending limbHigh doses