2024
Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases
Peccatori N, Coppola M, Colombini A, Silvestri D, Bertorello N, Kiren V, Melchionda F, Mura R, Onofrillo D, Gobbi S, Mattera R, Vinti L, Casini T, Santoro N, Sperlì D, D’Ippolito C, Conter V, Biondi A, Rizzari C. Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases. 2024, 100202. DOI: 10.1016/j.ejcped.2024.100202.Peer-Reviewed Original ResearchDelayed methotrexate eliminationHigh-dose methotrexateAcute kidney injuryHigh-dose methotrexate cyclesHemato-oncological diseasesRescue therapyMethotrexate eliminationPediatric patientsMedical records of pediatric patientsRecords of pediatric patientsRecovery of renal functionPediatric hemato-oncology patientsElimination of MTXEffective rescue therapyPlasma MTX levelsTreat acute kidney injuryHemato-oncological patientsMethotrexate cyclesChemotherapy blockMulticenter experienceMTX levelsRenal functionMedian timeRetrospective studyRe-challenge
2023
The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity
Umano G, Cirillo G, Sanchez G, Rondinelli G, Foderini M, Ferrara S, Di Sessa A, Marzuillo P, Papparella A, Santoro N, del Giudice E. The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity. Obesity 2023, 31: 2359-2364. PMID: 37550829, DOI: 10.1002/oby.23835.Peer-Reviewed Original ResearchConceptsHomeostasis model assessmentInsulin resistanceDisposition indexLower whole-body insulin sensitivity indexModel assessmentWhole-body insulin sensitivity indexRisk of prediabetesHigher fasting insulinLower disposition indexPlasma leptin levelsInsulin sensitivity indexBMI z-scoreLeptin plasma levelsLeptin gene transcriptionFasting insulinGlucose toleranceLeptin levelsCC patientsRetrospective studyPlasma levelsAnthropometrical evaluationInsulin sensitivityHormone levelsHigh prevalenceHigh risk