Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases
Peccatori N, Coppola M, Colombini A, Silvestri D, Bertorello N, Kiren V, Melchionda F, Mura R, Onofrillo D, Gobbi S, Mattera R, Vinti L, Casini T, Santoro N, Sperlì D, D’Ippolito C, Conter V, Biondi A, Rizzari C. Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases. 2024, 100202. DOI: 10.1016/j.ejcped.2024.100202.Peer-Reviewed Original ResearchDelayed methotrexate eliminationHigh-dose methotrexateAcute kidney injuryHigh-dose methotrexate cyclesHemato-oncological diseasesRescue therapyMethotrexate eliminationPediatric patientsMedical records of pediatric patientsRecords of pediatric patientsRecovery of renal functionPediatric hemato-oncology patientsElimination of MTXEffective rescue therapyPlasma MTX levelsTreat acute kidney injuryHemato-oncological patientsMethotrexate cyclesChemotherapy blockMulticenter experienceMTX levelsRenal functionMedian timeRetrospective studyRe-challenge