2017
Two Pools of Epoxyeicosatrienoic Acids in Humans
Elijovich F, Milne GL, Brown NJ, Laniado-Schwartzman M, Laffer CL. Two Pools of Epoxyeicosatrienoic Acids in Humans. Hypertension 2017, 71: 346-355. PMID: 29279315, PMCID: PMC5764817, DOI: 10.1161/hypertensionaha.117.10392.Peer-Reviewed Original ResearchConceptsSalt-resistant subjectsDihydroxyeicosatrienoic acidsEpoxyeicosatrienoic acidsBlood pressurePlasma epoxyeicosatrienoic acidsRegulation of natriuresisSalt-sensitive subjectsUrine sodium excretionPotential therapeutic implicationsRenal poolSodium excretionInpatient protocolNormotensive subjectsFractional excretionVascular dysfunctionVascular toneSystemic originTherapeutic implicationsTotal poolNatriuresisSalt loadingExcretionUrine poolsAldosteroneCatecholamines
2013
An LC–MS assay for the screening of cardiovascular medications in human samples
Dias E, Hachey B, McNaughton C, Nian H, Yu C, Straka B, Brown NJ, Caprioli RM. An LC–MS assay for the screening of cardiovascular medications in human samples. Journal Of Chromatography B 2013, 937: 44-53. PMID: 24013190, PMCID: PMC3800555, DOI: 10.1016/j.jchromb.2013.08.010.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular AgentsChromatography, LiquidDrug MonitoringHumansLimit of DetectionLinear ModelsReproducibility of ResultsTandem Mass SpectrometryConceptsAngiotensin II receptor blockersDrug metabolitesCardiovascular drugsDrug classesHospitalized patientsSingle LC-MS/MS methodLC-MS assayLC-MS/MS methodII receptor blockersCalcium channel blockersCardiovascular drug classesClinical samplesDrug detectionSpiked samplesMS methodCardiovascular medicationsReceptor blockersBeta blockersMedication administrationChannel blockersEnzyme inhibitorsClinical settingBlockersDrugsSimultaneous analysis
2001
Quantification of BK1-5, the Stable Bradykinin Plasma Metabolite in Humans, by a Highly Accurate Liquid-Chromatographic Tandem Mass Spectrometric Assay
Murphey L, Hachey D, Vaughan D, Brown N, Morrow J. Quantification of BK1-5, the Stable Bradykinin Plasma Metabolite in Humans, by a Highly Accurate Liquid-Chromatographic Tandem Mass Spectrometric Assay. Analytical Biochemistry 2001, 292: 87-93. PMID: 11319821, DOI: 10.1006/abio.2001.5073.Peer-Reviewed Original ResearchMeSH KeywordsBradykininChromatography, LiquidHumansMass SpectrometryPeptide FragmentsQuality Control