2015
Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population
White MJ, Kodaman NM, Harder RH, Asselbergs FW, Vaughan DE, Brown NJ, Moore JH, Williams SM. Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. PLOS ONE 2015, 10: e0136379. PMID: 26322636, PMCID: PMC4556460, DOI: 10.1371/journal.pone.0136379.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Genetic variantsCircadian clock genesMost genetic studiesCardiovascular disease susceptibilityImportant genetic variantsActivator inhibitor-1Inhibitor-1Clock genesGenetic studiesGenetic effectsDisease susceptibilityArylsulfatase BMajor modulatorNovel associationsLack of overlapGenesPathway effectsMedian PAI-1European descentVariantsGeneticsPopulationSNPsCaucasian population
2011
Epistatic Interactions in Genetic Regulation of t-PA and PAI-1 Levels in a Ghanaian Population
Penrod NM, Poku KA, Vaughn D, Asselbergs FW, Brown NJ, Moore JH, Williams SM. Epistatic Interactions in Genetic Regulation of t-PA and PAI-1 Levels in a Ghanaian Population. PLOS ONE 2011, 6: e16639. PMID: 21304999, PMCID: PMC3031598, DOI: 10.1371/journal.pone.0016639.Peer-Reviewed Original ResearchConceptsEpistatic interactionsPAI-1 levelsRenin-angiotensin systemMultiple genetic effectsPathway-specific genesD polymorphismPAI-1Genetic architectureT-PASingle SNP analysisGenetic regulationCentral genesSpecific genesCardiovascular diseaseFibrinolytic systemSNP analysisGenetic effectsGenesCleavage of angiotensinogenPlasminogen activator inhibitor-1Plasma t-PAT-PA levelsTissue plasminogen activatorActivator inhibitor-1Enzyme cleavage