Featured Publications
ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting
Zwolinski N, Patel K, Vadivelu N, Kodumudi G, Kaye A. ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting. Current Pain And Headache Reports 2023, 27: 65-79. PMID: 37079258, PMCID: PMC10116112, DOI: 10.1007/s11916-023-01108-3.Peer-Reviewed Original ResearchConceptsSubstance use disordersSubstance use disorder patientsAmbulatory patientsUse disordersDisorder patientsERAS protocolPerioperative pain managementAmbulatory surgery settingHospital quality metricsAmbulatory surgical settingAmbulatory surgery casesPerioperative protocolPain managementAdverse outcomesAmbulatory surgeryPharmacodynamic profileSurgery settingAmbulatory proceduresSurgery casesClinical dataEarly recoveryAbused substancesSurgical settingPatientsSubspecialty groupsKetamine
Shergill S, Vadivelu N. Ketamine. 2023, 195-205. DOI: 10.1007/978-3-031-21291-8_13.Peer-Reviewed Original ResearchPost-operative pain controlPost-operative analgesiaSympathetic nervous systemMaintenance of anesthesiaMultiple surgical proceduresMu-opioid receptorsNMDA receptor antagonismComplete anestheticERAS protocolOperative analgesiaAnalgesic benefitPain controlPulmonary diseaseSeptic shockChronic painReceptor antagonismSubanesthetic dosesOpioid receptorsPotent analgesicSurgical proceduresHepatic enzymesNervous systemPartial agonistKetaminePatientsWeaning Protocols After Ambulatory Surgery
Aggarwal N, Zafar J, Kodumudi G, Vadivelu N, Laurans M, Rajput K. Weaning Protocols After Ambulatory Surgery. 2021, 369-377. DOI: 10.1007/978-3-030-55262-6_28.ChaptersHospital-based outpatient departmentsAmbulatory surgery centersPostoperative painUnplanned admissionsAmbulatory surgeryLong-term opioid usersNumber of surgeriesUnanticipated admissionMultimodal analgesiaOpioid prescriptionsPain medicationPerioperative analgesiaIntractable nauseaOutpatient departmentOpioid usersAmbulatory proceduresSurgery centersWeaning protocolHospital careOrthopedic proceduresSurgeryPainPatientsAdmissionMajor causeSpecial Considerations – Indwelling Spinal Cord Stimulators and Intrathecal Pumps
Beals C, Chow R, Vadivelu N, Rajput K. Special Considerations – Indwelling Spinal Cord Stimulators and Intrathecal Pumps. 2021, 335-343. DOI: 10.1007/978-3-030-55262-6_25.ChaptersSpinal cord stimulatorContinuous opioid useChronic pain patientsPaucity of literatureIT clonidineCentral sensitizationMultimodal analgesiaSystemic medicationsOpioid toleranceOpioid usePerioperative managementPain patientsPain physiciansPump dysfunctionIntrathecal pumpNeuraxial anesthesiaAmbulatory surgeryLong actingRegional anesthesiaPatientsSurgeryUnique subsetNormal functionAnesthesiaStimulatorNovel Regional Anesthesia for Outpatient Surgery
Li J, Lam D, King H, Credaroli E, Harmon E, Vadivelu N. Novel Regional Anesthesia for Outpatient Surgery. Current Pain And Headache Reports 2019, 23: 69. PMID: 31372836, DOI: 10.1007/s11916-019-0809-6.Peer-Reviewed Original ResearchConceptsNerve blockAdverse eventsOutpatient surgeryLower extremity nerve blocksPeripheral nerve blocksPotential adverse eventsProper patient managementPerioperative analgesiaAmbulatory surgerySafe modalityShoulder surgeryAmbulatory proceduresRegional anesthesiaPatient managementUltrasound guidanceProper patientLower riskSurgeryPatient choiceMultidisciplinary effortAnalgesiaAnesthesiaPatientsEndometriosis Pain Management: a Review
Carlyle D, Khader T, Lam D, Vadivelu N, Shiwlochan D, Yonghee C. Endometriosis Pain Management: a Review. Current Pain And Headache Reports 2020, 24: 49. PMID: 32671581, DOI: 10.1007/s11916-020-00884-6.Peer-Reviewed Original ResearchConceptsSurgical managementGnRH agonists/antagonistsNonsteroidal anti-inflammatory drugsPain management optionsAnti-inflammatory drugsAgonists/antagonistsNerve ablationPresacral neurectomyMedical managementTreatment modalitiesAromatase inhibitorsChallenging diseaseSurgical techniqueReviewThe purposeNeurectomyExperimental pharmaceuticalsManagement optionsAblationHysterectomyOophorectomyEndometriosisRegimensResectionDanazolPatientsUltrasound-Guided Neuraxial Anesthesia
Li J, Krishna R, Zhang Y, Lam D, Vadivelu N. Ultrasound-Guided Neuraxial Anesthesia. Current Pain And Headache Reports 2020, 24: 59. PMID: 32812182, DOI: 10.1007/s11916-020-00895-3.Peer-Reviewed Original ResearchConceptsNeuraxial anesthesiaHigher first-attempt success rateFirst-attempt success rateNon-obstetric patientsAcute pain managementAttempt success ratePurpose of ReviewTherePain managementRegional anesthesiaNeuraxial spacePatient safety implicationsVertebral levelAnesthesiaOverall efficacyRecent FindingsUltrasoundNeedle passPatient safetyCatheter visualizationUltrasound utilizationClinical accuracySuccess rateCommon typeClinical applicationUltrasoundPatients
2021
Pain Management in Former Addicts on Medication-Assisted Treatment (MAT) Program
Rajput K, Kodumudi G, Vadivelu N. Pain Management in Former Addicts on Medication-Assisted Treatment (MAT) Program. 2021, 309-325. DOI: 10.1007/978-3-030-55262-6_23.ChaptersMedication-assisted treatmentOpiate addictionPerioperative pain management strategiesAdequate pain reliefPain management strategiesFraction of patientsPharmacologic risk factorsRisk of withdrawalMechanism of actionOpioid prescriptionsPain reliefPain managementPerioperative concernsAmbulatory surgeryDischarge planningRisk factorsOpioid epidemicHeroin abuseGeneral populationDrug AdministrationTreatment programPatientsDrugsFormer addictsTreatment
2019
Challenges of Robotic Gynecologic Surgery in Morbidly Obese Patients and How to Optimize Success
Menderes G, Gysler SM, Vadivelu N, Silasi DA. Challenges of Robotic Gynecologic Surgery in Morbidly Obese Patients and How to Optimize Success. Current Pain And Headache Reports 2019, 23: 51. PMID: 31263977, DOI: 10.1007/s11916-019-0788-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObese patientsGynecologic surgeryRobotic gynecologic surgeryPerioperative riskRobotic surgeryInvasive approachInvasive surgeryAdequate preoperative optimizationMorbidly obese patientsNon-obese counterpartsUse of laparoscopyIncidence of mortalityGynecologic patientsPerioperative complicationsPreoperative optimizationPerioperative managementLaparoscopic approachObese populationOpen surgeryPostoperative managementHeart diseaseExtreme BMIPatientsSurgeryPhysiologic adaptations
2016
Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control.
Thomas DA, West M, Legler A, Maslin B, Kim RK, Vadivelu N. Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control. Current Drug Safety 2016, 11: 196-205. PMID: 27113953, DOI: 10.2174/1574886311666160426130444.Peer-Reviewed Original ResearchConceptsPain controlNonopioid analgesicsSide effectsContemporary pain managementOptimum pain controlPerioperative pain controlAcute postoperative painPostoperative pain controlMultiple side effectsNonopioid medicationsPostoperative painTolerant patientsPain managementSafety profileAnalgesicsRecent dataComorbiditiesMedicationsOpioidsPainPatientsSurgeryMainstayControl
2014
Transvaginal cholecystectomy learning curve
Wood SG, Dai F, Dabu-Bondoc S, Mikhael H, Vadivelu N, Duffy A, Roberts KE. Transvaginal cholecystectomy learning curve. Surgical Endoscopy 2014, 29: 1837-1841. PMID: 25294548, DOI: 10.1007/s00464-014-3873-3.Peer-Reviewed Original ResearchConceptsOperative timeTransvaginal cholecystectomyTVC patientsAcademic centersAverage age 41Learning curveResultsSixty-one patientsLaparoscopic cholecystectomy patientsAverage operative timeFellowship-trained surgeonsCholecystectomy patientsFemale patientsLC patientsMean ageMethodsThis studyAge 41PatientsSecond quartileSurgical repertoireSame time periodThird quartileLack of exposureFellowship trainingQuartileInterested surgeonsPerioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonistChromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy.
Saraswathy R, Anand S, Kunnumpurath SK, Kurian RJ, Kaye AD, Vadivelu N. Chromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy. Ochsner Journal 2014, 14: 339-42. PMID: 25249799, PMCID: PMC4171791.Peer-Reviewed Original ResearchType 2 diabetes mellitusPainful diabetic neuropathyDiabetic neuropathyAKR1B1 geneDiabetes mellitusChromosomal aberrationsNeuropathic pathogenesisTremendous morbidityDM patientsTreatment optionsNeuropathyOxidative DNA damageExon 1 mutationsPatientsControl groupPathophysiological processesCultured lymphocytesPatient samplesChromosomal damagePilot investigationHigh rateSignificant mutationsPossible mutationsDNA damageSignificant numberPractical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner.
Vadivelu N, Singh-Gill H, Kodumudi G, Kaye AJ, Urman RD, Kaye AD. Practical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner. Ochsner Journal 2014, 14: 426-33. PMID: 25249810, PMCID: PMC4171802.Peer-Reviewed Original ResearchPain managementDrug toleranceMultidisciplinary pain managementChronic pain statesMethadone maintenance programPain statesSupportive carePatient's painChronic painMedication diversionSubstance disordersUrine testingDrug interactionsDetailed historyPatientsPainPsychiatric conditionsTimely interventionPatient's addictionPrescription drugsSafe outcomeDrug abuseAddictive disordersHealthcare practitionersMedical observation
2013
Diabetic neuropathy
Vadivelu N. Diabetic neuropathy. International Journal Of Nutrition Pharmacology Neurological Diseases 2013, 3: 332-334. DOI: 10.4103/2231-0738.119839.Peer-Reviewed Original ResearchDiabetic neuropathyNerve conduction testsPainful diabetic neuropathyLong-term diabetesFoot examsCentral sensitizationNerve damageSerious complicationsTerm diabetesCommon siteNeuropathyConduction testsDiabetesCell damageOxidative stressPainGene therapyTreatmentPlant extractsComplicationsPatientsTherapyDamageSensitization
2012
Postoperative apnea, respiratory strategies, and pathogenesis mechanisms: a review
Kaye AD, Hollon MM, Vadivelu N, Kodumudi G, Kaye RJ, Bueno FR, Baluch AR. Postoperative apnea, respiratory strategies, and pathogenesis mechanisms: a review. Journal Of Anesthesia 2012, 27: 423-432. PMID: 23179739, DOI: 10.1007/s00540-012-1517-0.Peer-Reviewed Original ResearchConceptsPostoperative apneaPostoperative patientsPostoperative pulmonary complicationsTerms of mortalityPostoperative ventilationPulmonary complicationsHospital staySupportive careVentilation supportAirway maintenanceCerebral cortexAdequate oxygenationAortic bodiesDifferential diagnosisApneaPathogenesis mechanismsOxygenationPatientsRespiratory strategiesVentilationAdditional oxygenationPhysiological mechanismsCauseExtubationMorbidityGuidance with Complex Treatment Choices
Mitra S, Vadivelu N. Guidance with Complex Treatment Choices. 2012, 89-105. DOI: 10.1007/978-1-4614-5164-8_6.ChaptersMultidisciplinary Approach and Coordination of Care
Mitra S, Vadivelu N. Multidisciplinary Approach and Coordination of Care. 2012, 7-21. DOI: 10.1007/978-1-4614-5164-8_2.ChaptersPsychological stateQuality of lifePalliative careMultidisciplinary approachCoordination of careContinuity of careFragmentation of careLife-threatening diseaseMultiple domainsDisease modificationDisease progressionPatient formsNursing staffCare addressesMultifaceted careMultidisciplinary teamSocial workersPatientsCareTime pointsModest increaseSingle personOwn barriersDistressFunctioning
2011
Safety of spinal anesthesia in a patient with achondroplasia for cesarean section.
Mikhael H, Vadivelu N, Braveman F. Safety of spinal anesthesia in a patient with achondroplasia for cesarean section. Current Drug Safety 2011, 6: 130-1. PMID: 21375478, DOI: 10.2174/157488611795684668.Peer-Reviewed Original ResearchConceptsSpinal anesthesiaCesarean sectionLow-dose meperidineBupivacaine spinal anesthesiaLimited mouth openingCervical spine instabilityAdministration of anesthesiaObstetric patientsPotential complicationsLumbar scoliosisSpine instabilityDrug choiceVertebral anomaliesMouth openingAchondroplastic dwarfAnesthesiaPatientsCareful evaluationControversial reportsBony characteristicsAdministrationConsideration of riskSafetyParturientsComplications
2010
Managing Pain in the Addicted Patient
Dabu-Bondoc S, Zhang R, Vadivelu N. Managing Pain in the Addicted Patient. 2010, 671-697. DOI: 10.1007/978-0-387-87579-8_31.ChaptersIllicit drug usePain patientsDrug useChronic pain management settingsDrug abusePrescription drug dependenceMajor trauma patientsChronic pain patientsPain management settingsGeneral medical practiceIllicit drugsSubstance abuse disordersSuch high prevalenceHospital admissionPain treatmentTrauma patientsSymptom managementRemote historyHigh prevalenceAddicted patientsAbuse disordersHigh incidencePatientsPathophysiological effectsPsychosocial issues