Availability and utilization of opioids for pain management: global issues.
Manjiani D, Paul DB, Kunnumpurath S, Kaye AD, Vadivelu N. Availability and utilization of opioids for pain management: global issues. Ochsner Journal 2014, 14: 208-15. PMID: 24940131, PMCID: PMC4052588.Peer-Reviewed Original ResearchPain managementHealth statusChronic opiate therapyIntractable painful conditionsPathophysiology of painUtilization of opioidsEffective pain reliefEffective pain managementPalliative care populationChronic pain managementAbnormal sleep patternsDaily living activitiesIndividual health statusOpiate therapyOpioid agentsPain reliefDiabetes mellitusOpioid deliveryChronic painCare populationChronic sufferersPain educationPainful conditionsChronic conditionsHeart diseaseChromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy.
Saraswathy R, Anand S, Kunnumpurath SK, Kurian RJ, Kaye AD, Vadivelu N. Chromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy. Ochsner Journal 2014, 14: 339-42. PMID: 25249799, PMCID: PMC4171791.Peer-Reviewed Original ResearchType 2 diabetes mellitusPainful diabetic neuropathyDiabetic neuropathyAKR1B1 geneDiabetes mellitusChromosomal aberrationsNeuropathic pathogenesisTremendous morbidityDM patientsTreatment optionsNeuropathyOxidative DNA damageExon 1 mutationsPatientsControl groupPathophysiological processesCultured lymphocytesPatient samplesChromosomal damagePilot investigationHigh rateSignificant mutationsPossible mutationsDNA damageSignificant number