Featured Publications
Ketamine
Shergill S, Vadivelu N. Ketamine. 2023, 195-205. DOI: 10.1007/978-3-031-21291-8_13.Peer-Reviewed Original ResearchPost-operative pain controlPost-operative analgesiaSympathetic nervous systemMaintenance of anesthesiaMultiple surgical proceduresMu-opioid receptorsNMDA receptor antagonismComplete anestheticERAS protocolOperative analgesiaAnalgesic benefitPain controlPulmonary diseaseSeptic shockChronic painReceptor antagonismSubanesthetic dosesOpioid receptorsPotent analgesicSurgical proceduresHepatic enzymesNervous systemPartial agonistKetaminePatientsAnalgesia for Gynecologic Oncologic Surgeries: A Narrative Review
Patel K, Shergill S, Vadivelu N, Rajput K. Analgesia for Gynecologic Oncologic Surgeries: A Narrative Review. Current Pain And Headache Reports 2022, 26: 1-13. PMID: 35118596, DOI: 10.1007/s11916-022-00998-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHyperthermic intraperitoneal chemotherapyCytoreductive surgeryPain managementNarrative reviewOptimal perioperative pain managementGynecologic oncologic surgeryPerioperative analgesic planPostoperative pain managementPerioperative pain managementLocal anesthetic infiltrationInvasive cancer surgeryMultimodal analgesicsPreemptive analgesiaMultimodal analgesiaPostoperative painAnalgesic planAnesthetic infiltrationGynecologic malignanciesIntraperitoneal chemotherapyPerioperative periodSurgery protocolThoracic epiduralCancer surgeryChronic painNeuraxial techniques
2016
Role of Alternative Therapies for Chronic Pain Syndromes
Thomas DA, Maslin B, Legler A, Springer E, Asgerally A, Vadivelu N. Role of Alternative Therapies for Chronic Pain Syndromes. Current Pain And Headache Reports 2016, 20: 29. PMID: 27038968, DOI: 10.1007/s11916-016-0562-z.Peer-Reviewed Original ResearchConceptsChronic painWhole-body cryotherapyExercise therapyPain statesAlternative therapiesComplimentary therapiesLong-term pain statesChronic pain syndromePhysical exercise therapyTreatment of headacheCognitive behavior therapyNeck painPain syndromeAlternate therapyBiofeedback therapyPain psychologySham controlsPainHerbal supplementsAlternative medicineTherapyBiopsychosocial approachBehavior therapyBiopsychosocial modelNew modality
2014
Intrathecal drug delivery for chronic pain management-scope, limitations and future
Czernicki M, Sinovich G, Mihaylov I, Nejad B, Kunnumpurath S, Kodumudi G, Vadivelu N. Intrathecal drug delivery for chronic pain management-scope, limitations and future. Journal Of Clinical Monitoring And Computing 2014, 29: 241-249. PMID: 25173564, DOI: 10.1007/s10877-014-9607-1.Peer-Reviewed Original ResearchConceptsIntrathecal drug delivery systemsChronic painOptimal medical managementIntrathecal drug deliveryDifferent implantation techniquesLicensing of drugsSevere morbidityMedical managementMuscle spasmMain indicationsIntrathecal useInvasive techniquesOutcome studiesPainAdverse effectsHealthcare practitionersImplantation techniqueTherapyDrug delivery systemsTherapy systemReview articleDelivery systemDate knowledgeMorbiditySpasmAvailability and utilization of opioids for pain management: global issues.
Manjiani D, Paul DB, Kunnumpurath S, Kaye AD, Vadivelu N. Availability and utilization of opioids for pain management: global issues. Ochsner Journal 2014, 14: 208-15. PMID: 24940131, PMCID: PMC4052588.Peer-Reviewed Original ResearchPain managementHealth statusChronic opiate therapyIntractable painful conditionsPathophysiology of painUtilization of opioidsEffective pain reliefEffective pain managementPalliative care populationChronic pain managementAbnormal sleep patternsDaily living activitiesIndividual health statusOpiate therapyOpioid agentsPain reliefDiabetes mellitusOpioid deliveryChronic painCare populationChronic sufferersPain educationPainful conditionsChronic conditionsHeart diseasePractical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner.
Vadivelu N, Singh-Gill H, Kodumudi G, Kaye AJ, Urman RD, Kaye AD. Practical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner. Ochsner Journal 2014, 14: 426-33. PMID: 25249810, PMCID: PMC4171802.Peer-Reviewed Original ResearchPain managementDrug toleranceMultidisciplinary pain managementChronic pain statesMethadone maintenance programPain statesSupportive carePatient's painChronic painMedication diversionSubstance disordersUrine testingDrug interactionsDetailed historyPatientsPainPsychiatric conditionsTimely interventionPatient's addictionPrescription drugsSafe outcomeDrug abuseAddictive disordersHealthcare practitionersMedical observation
2013
Patient considerations in the use of tapentadol for moderate to severe pain
Vadivelu N, Huang Y, Mirante B, Jacoby M, Braveman FR, Hines RL, Sinatra R. Patient considerations in the use of tapentadol for moderate to severe pain. Drug Healthcare And Patient Safety 2013, Volume 5: 151-159. PMID: 23861601, PMCID: PMC3704302, DOI: 10.2147/dhps.s28829.Peer-Reviewed Original ResearchTapentadol ERTapentadol IRSevere painChronic painOpioid agonistsClinical trialsSide effectsChronic painful diabetic neuropathyMu-opioid receptor agonistCentral nervous system depressantsSimilar pain reliefTraditional opioid agonistsUncontrolled postoperative painSevere acute painSevere chronic painGastrointestinal adverse effectsPainful diabetic neuropathyCommon side effectsNorepinephrine reuptake inhibitorsPost-surgical patientsOpioid receptor agonistsUse of tapentadolDrug Administration approvalMonoamine oxidase inhibitorsPotent opioid agonist
2009
Pain Pathways and Acute Pain Processing
McQuay H, Vadivelu N, Whitney C, Sinatra R. Pain Pathways and Acute Pain Processing. 2009, 3-20. DOI: 10.1017/cbo9780511576706.003.ChaptersPain pathwaysPain managementAcute pain managementPatient-controlled analgesiaAcute pain processingRole of anesthesiologistsAnalgesic optionsPain serviceAcute painSevere painChronic painPain assessmentPain processingTherapeutic guidelinesOptimal carePainAnalgesiaPatientsChronicityPathophysiologyOptionsAnesthesiologistsCliniciansPathwayIncidence
2008
Management of chronic pain in the elderly: focus on transdermal buprenorphine
Vadivelu N, Hines RL. Management of chronic pain in the elderly: focus on transdermal buprenorphine. Clinical Interventions In Aging 2008, Volume 3: 421-430. PMID: 18982913, PMCID: PMC2682375, DOI: 10.2147/cia.s1880.Peer-Reviewed Original ResearchConceptsChronic painTransdermal buprenorphineSafety profileChronic cancer painChronic nonmalignant painNew treatment optionsRelative safety profileCancer painNonmalignant painRespiratory depressionRenal failureTreatment optionsAnalgesic agentsCeiling doseAnalgesic propertiesPainSide effectsClinical practiceBuprenorphineOlder individualsCeiling effectsMetabolic changesDose dumpingSafe useRecent scientific studiesArticle Commentary: Pain after Mastectomy and Breast Reconstruction
Vadivelu N, Schreck M, Lopez J, Kodumudi G, Narayan D. Article Commentary: Pain after Mastectomy and Breast Reconstruction. The American Surgeon 2008, 74: 285-296. PMID: 18453290, DOI: 10.1177/000313480807400402.Peer-Reviewed Original ResearchConceptsSentinel node biopsyBreast cancerBreast reconstructionNode biopsyEarly treatmentInvasive therapyAcute post-operative painAcute nociceptive painPost-mastectomy painChronic neuropathic painChronic pain statesPost-operative painBreast-Conserving TherapyBreast cancer surgeryNeuropathic painPostoperative painNociceptive painOperative painPain statesCancer surgeryChronic painPhantom painPainMastectomyTherapy
2005
Recent advances in elucidating pain mechanisms
Vadivelu N, Sinatra R. Recent advances in elucidating pain mechanisms. Current Opinion In Anaesthesiology 2005, 18: 540. PMID: 16534290, DOI: 10.1097/01.aco.0000183109.27297.75.Peer-Reviewed Original ResearchCentral sensitizationPain mechanismsChronic painN-methyl-D-asparate antagonistNon-opioid medicationsSpinal cord hyperexcitabilityCyclooxygenase-2 inhibitorNew synaptic connectionsSecondary hyperalgesiaOpioid medicationsPain controlPain syndromeNerve injuryPain modulationPain statesNociceptor sensitizationNeural injuryNew opioidSecond messenger systemsNervous systemAcute tissueSynaptic connectionsReceptor systemMessenger systemsSensitization