2024
An In Vivo High-Resolution Human Brain Atlas of Synaptic Density
Johansen A, Beliveau V, Colliander E, Raval N, Dam V, Gillings N, Aznar S, Svarer C, Plavén-Sigray P, Knudsen G. An In Vivo High-Resolution Human Brain Atlas of Synaptic Density. Journal Of Neuroscience 2024, 44: e1750232024. PMID: 38997157, PMCID: PMC11326867, DOI: 10.1523/jneurosci.1750-23.2024.Peer-Reviewed Original ResearchPathogenesis of brain disordersBrain disordersHuman brainFunctional topographySynaptic densityBrain physiologySynapse densityHigher-order cortical areasSynaptic vesicle glycoprotein 2AHuman brain physiologyHealthy human brainSV2A densityPET neuroimagingComparative neuroscienceNeuroscience researchCortical areasBrainAutoradiography dataDisordersNeuroscienceBrain atlasesHealthy humansSV2APositive associationMRNA patternsSynaptic density patterns in early Alzheimer’s disease assessed by independent component analysis
Fang X, Raval N, O’Dell R, Naganawa M, Mecca A, Chen M, van Dyck C, Carson R. Synaptic density patterns in early Alzheimer’s disease assessed by independent component analysis. Brain Communications 2024, 6: fcae107. PMID: 38601916, PMCID: PMC11004947, DOI: 10.1093/braincomms/fcae107.Peer-Reviewed Original ResearchMedial temporal brain regionsAlzheimer's diseaseTemporal brain regionsCognitive deficitsBrain regionsCognitive impairmentPostmortem studiesBinds to SV2ASynaptic densityReduction of synaptic densityIndependent component analysisSynaptic lossAlzheimerDeficitsImpairmentBrainNeocortexComponent analysisPrimary pathologySV2A
2021
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease
Raval NR, Gudmundsen F, Juhl M, Andersen IV, Speth N, Videbæk A, Petersen IN, Mikkelsen JD, Fisher PM, Herth MM, Plavén-Sigray P, Knudsen GM, Palner M. Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease. Frontiers In Synaptic Neuroscience 2021, 13: 715811. PMID: 34867258, PMCID: PMC8636601, DOI: 10.3389/fnsyn.2021.715811.Peer-Reviewed Original ResearchNeuronal metabolic functionPositron emission tomographyParkinson's diseaseSynaptic densityCortical regionsJ bindingDopaminergic lesionVentral midbrainEmission tomographyIpsilateral ventral midbrainLower synaptic densityRostral substantia nigraUnilateral dopaminergic lesionNon-motor symptomsThalamo-cortical circuitsMetabolic functionsMedial forebrain bundleHigh synaptic densityMedial prefrontal cortexCerebral changesMotor dysfunctionUnilateral injectionDopaminergic neuronsSubstantia nigraBasal gangliaA Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain
Raval NR, Johansen A, Donovan LL, Ros NF, Ozenne B, Hansen HD, Knudsen GM. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain. International Journal Of Molecular Sciences 2021, 22: 835. PMID: 33467676, PMCID: PMC7830000, DOI: 10.3390/ijms22020835.Peer-Reviewed Original ResearchConceptsAntidepressive effectsR densitySingle dosePig brainSerotonin 2A receptor agonistSynaptic vesicle protein 2AAntidepressant effectsAntidepressive actionReceptor agonistAcute decreaseSynaptic densityReceptor densityCortex sectionsAwake pigsHippocampusDoseProtein 2ASynaptogenesisBrainPsilocybinPigsDaysAgonistsRadioligand