Featured Publications
Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography
Raval N, Angarita G, Matuskey D, Miller R, Drake L, Kapinos M, Nabulsi N, Huang Y, Carson R, O’Malley S, Cosgrove K, Hillmer A. Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography. Molecular Psychiatry 2023, 28: 3384-3390. PMID: 37532797, PMCID: PMC10743097, DOI: 10.1038/s41380-023-02198-6.Peer-Reviewed Original ResearchConceptsVolume of distributionBlood alcohol levelsPositron emission tomographyBrain immune responseImmune responseAlcohol challengeEmission tomographyPeak blood alcohol levelsMultilinear analysis 1Peripheral immune functionVivo human evidenceLaboratory alcohol challengeTSPO positron emission tomographyBinge levelsPlasma cytokinesImmune dysfunctionNeuroimmune systemIL-6MCP-1Cytokines TNFAcute effectsScan dayArterial bloodHuman evidenceImmune function
2023
Pretargeted imaging beyond the blood–brain barrier
Shalgunov V, van den Broek S, Andersen I, Vázquez R, Raval N, Palner M, Mori Y, Schäfer G, Herrmann B, Mikula H, Beschorner N, Nedergaard M, Syvänen S, Barz M, Knudsen G, Battisti U, Herth M. Pretargeted imaging beyond the blood–brain barrier. RSC Medicinal Chemistry 2023, 14: 444-453. PMID: 36970152, PMCID: PMC10034008, DOI: 10.1039/d2md00360k.Peer-Reviewed Original ResearchRational drug design approachDrug design approachBioorthogonal chemistryTetrazine ligationAttractive reactionPhysicochemical propertiesFluorine-18Blood-brain barrierLead compoundsMolecular imaging technologySoluble oligomersPositron emission tomographyBiomarker proteinsIdeal radionuclideTetrazineChemistryFavorable characteristicsDrug developmentOligomersPropertiesPretargetingNanomedicineCompoundsStructureReaction
2022
Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies
Raval NR, Wetherill RR, Wiers CE, Dubroff JG, Hillmer AT. Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies. Seminars In Nuclear Medicine 2022, 53: 213-229. PMID: 36270830, PMCID: PMC11261531, DOI: 10.1053/j.semnuclmed.2022.08.008.Peer-Reviewed Original Research In PressConceptsNeuroimmune targetsImmune systemNeuropsychiatric conditionsSphingosine-1-phosphate receptor 1Brain immune systemPurinergic P2X7 receptorVivo positron emission tomography (PET) imagingNitric oxide synthasePurinergic P2Y12 receptorPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyTranslocator protein 18Neuroimmune responsePET findingsNeuroimmune systemP2X7 receptorCyclooxygenase-2Oxide synthaseP2Y12 receptorPET resultsMonoamine oxidase BCyclooxygenase-1Colony-stimulating factor-1Receptor 1An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates
Raval NR, Nasser A, Madsen CA, Beschorner N, Beaman EE, Juhl M, Lehel S, Palner M, Svarer C, Plavén-Sigray P, Jørgensen LM, Knudsen GM. An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates. Frontiers In Neuroscience 2022, 16: 847074. PMID: 35368260, PMCID: PMC8966485, DOI: 10.3389/fnins.2022.847074.Peer-Reviewed Original ResearchPositron emission tomographyNovel radioligandPig modelAlzheimer's diseaseEmission tomographyΑ-synucleinGood translational modelΑ-synuclein pathologyBlood-brain barrierPostmortem human brain tissueReference tissue model 2Gadolinium-enhanced MRILarge animal modelNovel positron emission tomographyHuman brain tissueTimes higher uptakeCerebral injectionLewy bodiesVivo pig modelSaline injectionEssential clinical toolOccipital cortexParkinson's diseaseAppropriate radioligandsPET scans
2021
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease
Raval NR, Gudmundsen F, Juhl M, Andersen IV, Speth N, Videbæk A, Petersen IN, Mikkelsen JD, Fisher PM, Herth MM, Plavén-Sigray P, Knudsen GM, Palner M. Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease. Frontiers In Synaptic Neuroscience 2021, 13: 715811. PMID: 34867258, PMCID: PMC8636601, DOI: 10.3389/fnsyn.2021.715811.Peer-Reviewed Original ResearchNeuronal metabolic functionPositron emission tomographyParkinson's diseaseSynaptic densityCortical regionsJ bindingDopaminergic lesionVentral midbrainEmission tomographyIpsilateral ventral midbrainLower synaptic densityRostral substantia nigraUnilateral dopaminergic lesionNon-motor symptomsThalamo-cortical circuitsMetabolic functionsMedial forebrain bundleHigh synaptic densityMedial prefrontal cortexCerebral changesMotor dysfunctionUnilateral injectionDopaminergic neuronsSubstantia nigraBasal ganglia