2022
Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs
Raval N, Madsen C, Shalgunov V, Nasser A, Battisti U, Beaman E, Juhl M, Jørgensen L, Herth M, Hansen H, Plavén-Sigray P, Knudsen G. Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs. Nuclear Medicine And Biology 2022, 114: 42-48. PMID: 36095921, DOI: 10.1016/j.nucmedbio.2022.08.001.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseOccipital cortexΑ-synuclein pre-formed fibrilsInjected regionΑ-synuclein pathologyAD brain homogenatesDose-dependent effectPositron emission tomography (PET) radiotracerPre-formed fibrilsΑ-synuclein aggregatesReference regionAD homogenatesLogan graphical analysisLewy bodiesHistopathological hallmarksEarly diagnosisParkinson's diseasePET scansBrain homogenatesTime-activity curvesPig modelBrain regionsTomography radiotracerPig brainPET radiotracers
2021
A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain
Raval NR, Johansen A, Donovan LL, Ros NF, Ozenne B, Hansen HD, Knudsen GM. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain. International Journal Of Molecular Sciences 2021, 22: 835. PMID: 33467676, PMCID: PMC7830000, DOI: 10.3390/ijms22020835.Peer-Reviewed Original ResearchConceptsAntidepressive effectsR densitySingle dosePig brainSerotonin 2A receptor agonistSynaptic vesicle protein 2AAntidepressant effectsAntidepressive actionReceptor agonistAcute decreaseSynaptic densityReceptor densityCortex sectionsAwake pigsHippocampusDoseProtein 2ASynaptogenesisBrainPsilocybinPigsDaysAgonistsRadioligand