2021
Structural brain network characteristics in patients with episodic and chronic migraine
Michels L, Koirala N, Groppa S, Luechinger R, Gantenbein A, Sandor P, Kollias S, Riederer F, Muthuraman M. Structural brain network characteristics in patients with episodic and chronic migraine. The Journal Of Headache And Pain 2021, 22: 8. PMID: 33657996, PMCID: PMC7927231, DOI: 10.1186/s10194-021-01216-8.Peer-Reviewed Original Research
2020
Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS
Muthuraman M, Fleischer V, Kroth J, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth S, Zipp F, Groppa S. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e681. PMID: 32024782, PMCID: PMC7051213, DOI: 10.1212/nxi.0000000000000681.Peer-Reviewed Original ResearchConceptsCortical atrophyDisability progressionLesion distributionWM lesionsEarly relapsing-remitting MSShort-term disability progressionWhite matter lesion distributionDisability Status Scale scoreRapid clinical deteriorationRelapsing-remitting MSStatus Scale scoreWhite matter lesionsIndividual patient outcomesLeft-lateralized patternClinical worseningClinical deteriorationClinical disabilityFunctional disabilityStudy cohortMatter lesionsEarly MSPatient outcomesHigh riskIndependent cohortSecond cohort
2019
Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine
Michels L, Villanueva J, O’Gorman R, Muthuraman M, Koirala N, Büchler R, Gantenbein A, Sandor P, Luechinger R, Kollias S, Riederer F. Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine. Headache The Journal Of Head And Face Pain 2019, 59: 1808-1820. PMID: 31680242, DOI: 10.1111/head.13646.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebrovascular CirculationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMigraine DisordersSpin LabelsVisual CortexYoung AdultConceptsCerebral blood flowCohen's d effect sizesEpisodic migraineD effect sizesHealthy controlsSuperior temporal gyrusASL-MRIVisual cortexInterictal cerebral blood flowInterictal stateTemporal gyrusHigher-order visual cortexNeuro-functional abnormalitiesEffect sizeFunctional brain imaging studiesNon-invasive imaging methodMagnetic resonance imagingHigher visual cortexBrain imaging studiesInterictal hyperperfusionCBF changesSubcortical alterationsMigraine pathophysiologyParietal operculumBlood flowLarge-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures
Chiosa V, Ciolac D, Groppa S, Koirala N, Pintea B, Vataman A, Winter Y, Gonzalez-Escamilla G, Muthuraman M, Groppa S. Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures. Sleep 2019, 42: zsz006. PMID: 30753617, DOI: 10.1093/sleep/zsz006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingCerebral CortexEpilepsyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetSeizuresSleepWakefulnessYoung AdultConceptsAwake seizuresSleep seizuresHealthy controlsAwake stateSex-matched healthy controlsRight middle temporal cortexDifferent epilepsy typesVolume of hippocampusBrain networksMiddle temporal cortexEpilepsy typePathophysiological alterationsSubcortical abnormalitiesPatientsTemporal cortexSeizuresSubcortical regionsSuperior temporalBilateral insulaOrbitofrontal cortexSleepParietal regionsAbnormalitiesRight hemisphereStructural correlates
2018
Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors
Muthuraman M, Raethjen J, Koirala N, Anwar A, Mideksa K, Elble R, Groppa S, Deuschl G. Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain 2018, 141: 1770-1781. PMID: 29701820, DOI: 10.1093/brain/awy098.Peer-Reviewed Original ResearchConceptsEssential tremorSensorimotor cortexCerebral cortexHealthy controlsPremotor cortexParkinson's diseaseVoluntary rhythmic movementsPrimary sensorimotor cortexSex-matched groupPrimary sensorimotor regionsEEG-EMG coherenceMotor performance measuresParkinson's tremorEMG oscillationsCortical efferentsSensorimotor regionsCerebellar involvementTremor severityFunctional MRICortexCerebellumDiseaseAdditional studiesTremorMulti-channel EMG
2017
Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease
Koirala N, Fleischer V, Glaser M, Zeuner K, Deuschl G, Volkmann J, Muthuraman M, Groppa S. Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease. Brain Topography 2017, 31: 311-321. PMID: 28986718, DOI: 10.1007/s10548-017-0597-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedDeep Brain StimulationFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseSubthalamic NucleusTreatment OutcomeConceptsDeep brain stimulationDiffusion-weighted imagingPostoperative clinical outcomesClinical responseParkinson's diseaseSTN-DBSClinical outcomesSubthalamic nucleusBrain stimulationSubthalamic nucleus deep brain stimulationNon-motor symptomsOptimal clinical responseConnectivity profilesPre-intervention predictorsEvidence-based stateIndependent predictorsPD patientsTherapy optionsClinical effectivenessCingulate gyrusFrontal lobe connectivityCerebral regionsT MRI scannerCerebral networksPrefrontal cortexEffects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchMeSH KeywordsAgedDeep Brain StimulationFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityParkinson DiseaseSubthalamic NucleusTreatment OutcomeWorkflowConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation
2016
Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy
Alexandru H, Muthuraman M, Chirumamilla V, Koirala N, Paktas B, Deuschl G, Zeuner K, Groppa S. Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLOS ONE 2016, 11: e0168652. PMID: 27992533, PMCID: PMC5161386, DOI: 10.1371/journal.pone.0168652.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlepharospasmBotulinum ToxinsCross-Sectional StudiesFemaleGray MatterHemifacial SpasmHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedTreatment OutcomeConceptsBenign essential blepharospasmHemifacial spasmBoNT therapyCortical thicknessBEB patientsHealthy controlsTemporal poleCommon hyperkinetic movement disordersStandard evidence-based treatmentGroup of patientsBotulinum neurotoxin therapyHyperkinetic movement disordersPrimary motor cortexDifferent pathophysiological mechanismsLower cortical thicknessEvidence-based treatmentsFacial musclesPre-supplementary motor areaRight superior frontal regionsGroup of ageLeft lingual gyrusSuperior frontal regionsGray matter integrityContrary patientsNeurotoxin therapy
2015
Testing the effects of pre-processing on voxel based morphometry analysis
Chaitanya C, Koirala N, Mideksa K, Anwar A, Schmidt G, Deuschl G, Groppa S, Muthuraman M. Testing the effects of pre-processing on voxel based morphometry analysis. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2015, 2015: 4302-4305. PMID: 26737246, DOI: 10.1109/embc.2015.7319346.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesGray MatterHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingConceptsGray matter volumeGray matter differencesDifferent time pointsTime pointsMagnetic resonance imagesBotulinum toxin injectionEvidence-based therapiesStructural grey matter differencesVoxel-wise comparisonBase therapyToxin injectionCross-sectional data analysisBotulinum toxinMatter volumeRespective musclesMorphometry analysisLongitudinal data analysisPatientsLongitudinal analysisResonance imagesInjectionBrainTreatmentSecond aimStatistical analysis