2022
Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea
Bahr-Hamm K, Koirala N, Hanif M, Gouveris H, Muthuraman M. Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea. International Journal Of Molecular Sciences 2022, 24: 47. PMID: 36613490, PMCID: PMC9820672, DOI: 10.3390/ijms24010047.Peer-Reviewed Original ResearchConceptsModerate OSA patientsSevere OSASensorimotor cortical activityOSA patientsRespiratory arousalsCortical activityObstructive sleep apnea patientsSevere OSA patientsObstructive sleep apneaSignificant decreaseSleep apnea patientsSleep stagesRaw electroencephalography dataModerate OSASleep apneaRespiratory eventsApnea patientsDifferential diagnosisSleep stage N1PatientsAutonomic activationStage N1Cortical arousalPathophysiologic traitsOSA
2020
Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS
Muthuraman M, Fleischer V, Kroth J, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth S, Zipp F, Groppa S. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e681. PMID: 32024782, PMCID: PMC7051213, DOI: 10.1212/nxi.0000000000000681.Peer-Reviewed Original ResearchConceptsCortical atrophyDisability progressionLesion distributionWM lesionsEarly relapsing-remitting MSShort-term disability progressionWhite matter lesion distributionDisability Status Scale scoreRapid clinical deteriorationRelapsing-remitting MSStatus Scale scoreWhite matter lesionsIndividual patient outcomesLeft-lateralized patternClinical worseningClinical deteriorationClinical disabilityFunctional disabilityStudy cohortMatter lesionsEarly MSPatient outcomesHigh riskIndependent cohortSecond cohort
2019
Gray matter integrity predicts white matter network reorganization in multiple sclerosis
Radetz A, Koirala N, Krämer J, Johnen A, Fleischer V, Gonzalez‐Escamilla G, Cerina M, Muthuraman M, Meuth S, Groppa S. Gray matter integrity predicts white matter network reorganization in multiple sclerosis. Human Brain Mapping 2019, 41: 917-927. PMID: 32026599, PMCID: PMC7268008, DOI: 10.1002/hbm.24849.Peer-Reviewed Original ResearchConceptsDeep gray matter volumesGray matter volumeMultiple sclerosisGray matter integrityMatter volumeWhite matter networksEarly relapsing-remitting multiple sclerosisRelapsing-remitting multiple sclerosisTime pointsGray matter atrophyDeep gray matter structuresCognitive performanceMiddle temporal cortexGray matter structuresGray matter regionsDisability progressionBrain stemMatter damageSignificant atrophyMatter atrophyDeep gray matter regionsCortical thicknessTemporal cortexTissue damageAtrophyInterictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine
Michels L, Villanueva J, O’Gorman R, Muthuraman M, Koirala N, Büchler R, Gantenbein A, Sandor P, Luechinger R, Kollias S, Riederer F. Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine. Headache The Journal Of Head And Face Pain 2019, 59: 1808-1820. PMID: 31680242, DOI: 10.1111/head.13646.Peer-Reviewed Original ResearchConceptsCerebral blood flowCohen's d effect sizesEpisodic migraineD effect sizesHealthy controlsSuperior temporal gyrusASL-MRIVisual cortexInterictal cerebral blood flowInterictal stateTemporal gyrusHigher-order visual cortexNeuro-functional abnormalitiesEffect sizeFunctional brain imaging studiesNon-invasive imaging methodMagnetic resonance imagingHigher visual cortexBrain imaging studiesInterictal hyperperfusionCBF changesSubcortical alterationsMigraine pathophysiologyParietal operculumBlood flowCortical network fingerprints predict deep brain stimulation outcome in dystonia
Gonzalez‐Escamilla G, Muthuraman M, Reich M, Koirala N, Riedel C, Glaser M, Lange F, Deuschl G, Volkmann J, Groppa S. Cortical network fingerprints predict deep brain stimulation outcome in dystonia. Movement Disorders 2019, 34: 1537-1546. PMID: 31433874, DOI: 10.1002/mds.27808.Peer-Reviewed Original ResearchConceptsDeep brain stimulationModerate-outcome groupDystonia patientsEffective evidence-based therapySuperior-outcome groupGlobus pallidus internusGrey matter atrophy patternsEvidence-based therapiesBrain network organizationClinical responseCortical atrophyDBS outcomesIndependent predictorsMotor improvementMulticenter cohortDBS implantationAtrophy patternsPreoperative MRITherapy responseVisuomotor areasCortical thicknessBrain stimulationCortical mantlePatientsUnequivocal predictorsSelective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis
Ciolac D, Luessi F, Gonzalez-Escamilla G, Koirala N, Riedel C, Fleischer V, Bittner S, Krämer J, Meuth S, Muthuraman M, Groppa S. Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis. Frontiers In Immunology 2019, 10: 1779. PMID: 31417557, PMCID: PMC6682686, DOI: 10.3389/fimmu.2019.01779.Peer-Reviewed Original ResearchConceptsCortical atrophyDisease activityMultiple sclerosisDMF groupDeep GM volumesDimethyl fumarate treatmentT-cell depletionDisease-modifying drugsWhite matter damageImmune cell dynamicsDMF therapyNAT patientsStrong CD8Lymphocyte subsetsDisease durationDisease courseMS patientsCell depletionMatter damageLess atrophyFumarate treatmentTreatment paradigmBrain network responsesLesion volumeTherapy responseLarge-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures
Chiosa V, Ciolac D, Groppa S, Koirala N, Pintea B, Vataman A, Winter Y, Gonzalez-Escamilla G, Muthuraman M, Groppa S. Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures. Sleep 2019, 42: zsz006. PMID: 30753617, DOI: 10.1093/sleep/zsz006.Peer-Reviewed Original ResearchConceptsAwake seizuresSleep seizuresHealthy controlsAwake stateSex-matched healthy controlsRight middle temporal cortexDifferent epilepsy typesVolume of hippocampusBrain networksMiddle temporal cortexEpilepsy typePathophysiological alterationsSubcortical abnormalitiesPatientsTemporal cortexSeizuresSubcortical regionsSuperior temporalBilateral insulaOrbitofrontal cortexSleepParietal regionsAbnormalitiesRight hemisphereStructural correlates
2017
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth S, Groppa S. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal 2017, 25: 338-343. PMID: 29226779, DOI: 10.1177/1352458517748474.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCortical atrophyRelapsing-remitting multiple sclerosisBlood-brain barrier integrityLongitudinal magnetic resonance imagingCerebrospinal fluid markersGray matter pathologyHigher functional disabilityCerebrospinal fluid albuminQuotient of albuminMagnetic resonance imagingCumulative disabilityClinical disabilityWidespread atrophyFunctional disabilityCSF concentrationsCSF markersDisease progressionFunctional deteriorationImmunoglobulin AAtrophy measurementsFluid markersUnequivocal predictorsBarrier integrityDisease evolutionBreakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies
Chiosa V, Groppa S, Ciolac D, Koirala N, Mişina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S. Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies. Brain Connectivity 2017, 7: 309-320. PMID: 28494616, DOI: 10.1089/brain.2017.0487.Peer-Reviewed Original ResearchConceptsFrontal lobeVentral anterior nucleusThalamo-cortical connectivityFuture therapeutic approachesSpike generationFocal epileptic seizuresMedial dorsalThalamic volumeFocal epilepsyAnterior nucleusFrontal cortexTherapeutic approachesEpileptic seizuresCerebral networksCortical integrityThalamusEEG recordingsWidespread areasDistinct patternsLobeEpileptogenesisPatientsEpilepsySeizuresCortex
2016
Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy
Alexandru H, Muthuraman M, Chirumamilla V, Koirala N, Paktas B, Deuschl G, Zeuner K, Groppa S. Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLOS ONE 2016, 11: e0168652. PMID: 27992533, PMCID: PMC5161386, DOI: 10.1371/journal.pone.0168652.Peer-Reviewed Original ResearchConceptsBenign essential blepharospasmHemifacial spasmBoNT therapyCortical thicknessBEB patientsHealthy controlsTemporal poleCommon hyperkinetic movement disordersStandard evidence-based treatmentGroup of patientsBotulinum neurotoxin therapyHyperkinetic movement disordersPrimary motor cortexDifferent pathophysiological mechanismsLower cortical thicknessEvidence-based treatmentsFacial musclesPre-supplementary motor areaRight superior frontal regionsGroup of ageLeft lingual gyrusSuperior frontal regionsGray matter integrityContrary patientsNeurotoxin therapyIncreased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis
Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth S, Zipp F, Groppa S. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Multiple Sclerosis Journal 2016, 23: 432-441. PMID: 27246143, DOI: 10.1177/1352458516651503.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemMagnetic resonance imagingWhite matterClinical declineClinical impairmentRelapsing-remitting MS patientsEarly multiple sclerosisVoxel-based morphometryTemporo-parietal regionsNeuronal injuryConnectivity patternsMS patientsRemission phaseDisease stageDisease onsetHealthy controlsFunctional declineNervous systemGray matter networksResonance imagingProbabilistic tractographySclerosisStructural connectivityDisease