2020
Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS
Muthuraman M, Fleischer V, Kroth J, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth S, Zipp F, Groppa S. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e681. PMID: 32024782, PMCID: PMC7051213, DOI: 10.1212/nxi.0000000000000681.Peer-Reviewed Original ResearchConceptsCortical atrophyDisability progressionLesion distributionWM lesionsEarly relapsing-remitting MSShort-term disability progressionWhite matter lesion distributionDisability Status Scale scoreRapid clinical deteriorationRelapsing-remitting MSStatus Scale scoreWhite matter lesionsIndividual patient outcomesLeft-lateralized patternClinical worseningClinical deteriorationClinical disabilityFunctional disabilityStudy cohortMatter lesionsEarly MSPatient outcomesHigh riskIndependent cohortSecond cohort
2019
Gray matter integrity predicts white matter network reorganization in multiple sclerosis
Radetz A, Koirala N, Krämer J, Johnen A, Fleischer V, Gonzalez‐Escamilla G, Cerina M, Muthuraman M, Meuth S, Groppa S. Gray matter integrity predicts white matter network reorganization in multiple sclerosis. Human Brain Mapping 2019, 41: 917-927. PMID: 32026599, PMCID: PMC7268008, DOI: 10.1002/hbm.24849.Peer-Reviewed Original ResearchConceptsDeep gray matter volumesGray matter volumeMultiple sclerosisGray matter integrityMatter volumeWhite matter networksEarly relapsing-remitting multiple sclerosisRelapsing-remitting multiple sclerosisTime pointsGray matter atrophyDeep gray matter structuresCognitive performanceMiddle temporal cortexGray matter structuresGray matter regionsDisability progressionBrain stemMatter damageSignificant atrophyMatter atrophyDeep gray matter regionsCortical thicknessTemporal cortexTissue damageAtrophySelective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis
Ciolac D, Luessi F, Gonzalez-Escamilla G, Koirala N, Riedel C, Fleischer V, Bittner S, Krämer J, Meuth S, Muthuraman M, Groppa S. Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis. Frontiers In Immunology 2019, 10: 1779. PMID: 31417557, PMCID: PMC6682686, DOI: 10.3389/fimmu.2019.01779.Peer-Reviewed Original ResearchConceptsCortical atrophyDisease activityMultiple sclerosisDMF groupDeep GM volumesDimethyl fumarate treatmentT-cell depletionDisease-modifying drugsWhite matter damageImmune cell dynamicsDMF therapyNAT patientsStrong CD8Lymphocyte subsetsDisease durationDisease courseMS patientsCell depletionMatter damageLess atrophyFumarate treatmentTreatment paradigmBrain network responsesLesion volumeTherapy responseLarge-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures
Chiosa V, Ciolac D, Groppa S, Koirala N, Pintea B, Vataman A, Winter Y, Gonzalez-Escamilla G, Muthuraman M, Groppa S. Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures. Sleep 2019, 42: zsz006. PMID: 30753617, DOI: 10.1093/sleep/zsz006.Peer-Reviewed Original ResearchConceptsAwake seizuresSleep seizuresHealthy controlsAwake stateSex-matched healthy controlsRight middle temporal cortexDifferent epilepsy typesVolume of hippocampusBrain networksMiddle temporal cortexEpilepsy typePathophysiological alterationsSubcortical abnormalitiesPatientsTemporal cortexSeizuresSubcortical regionsSuperior temporalBilateral insulaOrbitofrontal cortexSleepParietal regionsAbnormalitiesRight hemisphereStructural correlates
2017
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth S, Groppa S. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal 2017, 25: 338-343. PMID: 29226779, DOI: 10.1177/1352458517748474.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCortical atrophyRelapsing-remitting multiple sclerosisBlood-brain barrier integrityLongitudinal magnetic resonance imagingCerebrospinal fluid markersGray matter pathologyHigher functional disabilityCerebrospinal fluid albuminQuotient of albuminMagnetic resonance imagingCumulative disabilityClinical disabilityWidespread atrophyFunctional disabilityCSF concentrationsCSF markersDisease progressionFunctional deteriorationImmunoglobulin AAtrophy measurementsFluid markersUnequivocal predictorsBarrier integrityDisease evolutionBreakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies
Chiosa V, Groppa S, Ciolac D, Koirala N, Mişina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S. Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies. Brain Connectivity 2017, 7: 309-320. PMID: 28494616, DOI: 10.1089/brain.2017.0487.Peer-Reviewed Original ResearchConceptsFrontal lobeVentral anterior nucleusThalamo-cortical connectivityFuture therapeutic approachesSpike generationFocal epileptic seizuresMedial dorsalThalamic volumeFocal epilepsyAnterior nucleusFrontal cortexTherapeutic approachesEpileptic seizuresCerebral networksCortical integrityThalamusEEG recordingsWidespread areasDistinct patternsLobeEpileptogenesisPatientsEpilepsySeizuresCortex