2022
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine 2022, 14: eabk0135. PMID: 35442704, DOI: 10.1126/scitranslmed.abk0135.Peer-Reviewed Original ResearchConceptsStroke outcomeExperimental strokeGlutamatergic transmissionCortical excitabilityATX concentrationsAstrocyte-specific deletionDifferent time pointsStroke eventsPerisynaptic processesExcess glutamateTherapeutic approachesAnimal modelsTransgenic miceEnzyme autotaxinLPA signalingATX inhibitionPharmacological inhibitionStrokeTranslational potentialTime pointsSingle nucleotide polymorphismsAutotaxinOutcomesExcitabilityInhibition
2020
Myelination- and immune-mediated MR-based brain network correlates
Cerina M, Muthuraman M, Gallus M, Koirala N, Dik A, Wachsmuth L, Hundehege P, Schiffler P, Tenberge J, Fleischer V, Gonzalez-Escamilla G, Narayanan V, Krämer J, Faber C, Budde T, Groppa S, Meuth S. Myelination- and immune-mediated MR-based brain network correlates. Journal Of Neuroinflammation 2020, 17: 186. PMID: 32532336, PMCID: PMC7293122, DOI: 10.1186/s12974-020-01827-z.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCentral nervous systemCorpus callosumBrain network characteristicsCuprizone dietAnxiety-like behaviorFractional anisotropy valuesDiffusion tensor imagingBackgroundMultiple sclerosisConsistent demyelinationMyelin dynamicsKey anatomical regionsCuprizone modelMyelin lossNeuropsychiatric symptomsAutoimmune diseasesFunctional impairmentNeurodegenerative processesHistopathological basisCortical areasMRI metricsDemyelinationDisease processNervous systemFA reduction