2021
Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease
Muthuraman M, Palotai M, Jávor-Duray B, Kelemen A, Koirala N, Halász L, Erőss L, Fekete G, Bognár L, Deuschl G, Tamás G. Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease. NeuroImage Clinical 2021, 32: 102857. PMID: 34662779, PMCID: PMC8526781, DOI: 10.1016/j.nicl.2021.102857.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesDeep Brain StimulationHumansHypokinesiaParkinson DiseaseSubthalamic NucleusConceptsSlope of changeContralateral stimulationPremotor cortexParkinson's diseasePrimary motorPresent cross-sectional studyBasal ganglia-thalamoBilateral subthalamic stimulationCross-sectional studyHigh beta frequency bandBeta frequency bandsParkinsonian patientsSubthalamic stimulationContralateral sideScreening periodSubthalamic nucleusBradykinesia severityCortical circuitsGamma frequency bandBradykinesiaDiseaseHigh-gamma frequency bandStimulation levelsStimulationCortex
2020
Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation
Koirala N, Serrano L, Paschen S, Falk D, Anwar A, Kuravi P, Deuschl G, Groppa S, Muthuraman M. Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation. Scientific Reports 2020, 10: 19241. PMID: 33159098, PMCID: PMC7648837, DOI: 10.1038/s41598-020-74196-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain MappingBrain WavesDeep Brain StimulationFemaleHumansMaleMiddle AgedParkinson DiseaseSubthalamic NucleusConceptsMicroelectrode recordingsBackground activityStereotactic magnetic resonance imagingLow beta frequency rangeDeep brain stimulation surgeryBilateral STN-DBSSide effect ratioDeep brain stimulationBeta frequency rangeMagnetic resonance imagingSTN-DBSAwake patientsLead placementSubthalamic nucleusIntraoperative decisionAnatomical sitesBrain stimulationDBS electrodesOptimal target localizationResonance imagingMaximum spike rateBeta rangeSpike ratePatientsImplantationCross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease
Muthuraman M, Bange M, Koirala N, Ciolac D, Pintea B, Glaser M, Tinkhauser G, Brown P, Deuschl G, Groppa S. Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease. Brain 2020, 143: 3393-3407. PMID: 33150359, PMCID: PMC7116448, DOI: 10.1093/brain/awaa297.Peer-Reviewed Original ResearchConceptsDeep brain stimulationBrain stimulationParkinson's diseaseStimulation frequencyCross-frequency couplingMotor symptomsSubthalamic nucleusGamma oscillationsDeep Brain Stimulation FrequencyOscillatory activityPhysiological neural activityMotor function recoveryEffective deep brain stimulationHigh-frequency stimulationPathological oscillatory activityCross-frequency interactionsCortico-subcortical networksDifferent oscillatory activitiesSymptom controlParietal cortex regionsClinical effectsFunction recoverySymptom alleviationMotor impairmentSubcortical regions
2019
Cortical network fingerprints predict deep brain stimulation outcome in dystonia
Gonzalez‐Escamilla G, Muthuraman M, Reich M, Koirala N, Riedel C, Glaser M, Lange F, Deuschl G, Volkmann J, Groppa S. Cortical network fingerprints predict deep brain stimulation outcome in dystonia. Movement Disorders 2019, 34: 1537-1546. PMID: 31433874, DOI: 10.1002/mds.27808.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesDeep Brain StimulationDystoniaDystonic DisordersFemaleGlobus PallidusHumansMaleMiddle AgedSeverity of Illness IndexConceptsDeep brain stimulationModerate-outcome groupDystonia patientsEffective evidence-based therapySuperior-outcome groupGlobus pallidus internusGrey matter atrophy patternsEvidence-based therapiesBrain network organizationClinical responseCortical atrophyDBS outcomesIndependent predictorsMotor improvementMulticenter cohortDBS implantationAtrophy patternsPreoperative MRITherapy responseVisuomotor areasCortical thicknessBrain stimulationCortical mantlePatientsUnequivocal predictors
2017
Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease
Koirala N, Fleischer V, Glaser M, Zeuner K, Deuschl G, Volkmann J, Muthuraman M, Groppa S. Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease. Brain Topography 2017, 31: 311-321. PMID: 28986718, DOI: 10.1007/s10548-017-0597-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedDeep Brain StimulationFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseSubthalamic NucleusTreatment OutcomeConceptsDeep brain stimulationDiffusion-weighted imagingPostoperative clinical outcomesClinical responseParkinson's diseaseSTN-DBSClinical outcomesSubthalamic nucleusBrain stimulationSubthalamic nucleus deep brain stimulationNon-motor symptomsOptimal clinical responseConnectivity profilesPre-intervention predictorsEvidence-based stateIndependent predictorsPD patientsTherapy optionsClinical effectivenessCingulate gyrusFrontal lobe connectivityCerebral regionsT MRI scannerCerebral networksPrefrontal cortexEffects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation
2016
Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;
Koirala N, Fleischer V, Granert O, Deuschl G, Muthuraman M, Groppa S. Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2016, 2016: 5533-5536. PMID: 28269510, DOI: 10.1109/embc.2016.7591980.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDeep brain stimulationSTN-DBSParkinson's diseaseDiffusion tensor imagingBrain stimulationProbabilistic tractographyActive DBS contactsPostoperative clinical outcomesPrimary motor cortexStandard therapeutic optionIdiopathic Parkinson's diseaseCortico-spinal tractSubcortical seedsClinical outcomesTherapeutic optionsDBS contactsMotor cortexDBS treatmentUniversity HospitalSubthalamic nucleusMotor areaPremotor regionsStimulation siteTensor imaging