2022
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine 2022, 14: eabk0135. PMID: 35442704, DOI: 10.1126/scitranslmed.abk0135.Peer-Reviewed Original ResearchConceptsStroke outcomeExperimental strokeGlutamatergic transmissionCortical excitabilityATX concentrationsAstrocyte-specific deletionDifferent time pointsStroke eventsPerisynaptic processesExcess glutamateTherapeutic approachesAnimal modelsTransgenic miceEnzyme autotaxinLPA signalingATX inhibitionPharmacological inhibitionStrokeTranslational potentialTime pointsSingle nucleotide polymorphismsAutotaxinOutcomesExcitabilityInhibition
2017
Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies
Chiosa V, Groppa S, Ciolac D, Koirala N, Mişina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S. Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies. Brain Connectivity 2017, 7: 309-320. PMID: 28494616, DOI: 10.1089/brain.2017.0487.Peer-Reviewed Original ResearchConceptsFrontal lobeVentral anterior nucleusThalamo-cortical connectivityFuture therapeutic approachesSpike generationFocal epileptic seizuresMedial dorsalThalamic volumeFocal epilepsyAnterior nucleusFrontal cortexTherapeutic approachesEpileptic seizuresCerebral networksCortical integrityThalamusEEG recordingsWidespread areasDistinct patternsLobeEpileptogenesisPatientsEpilepsySeizuresCortex