2021
Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease
Muthuraman M, Palotai M, Jávor-Duray B, Kelemen A, Koirala N, Halász L, Erőss L, Fekete G, Bognár L, Deuschl G, Tamás G. Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease. NeuroImage Clinical 2021, 32: 102857. PMID: 34662779, PMCID: PMC8526781, DOI: 10.1016/j.nicl.2021.102857.Peer-Reviewed Original ResearchConceptsSlope of changeContralateral stimulationPremotor cortexParkinson's diseasePrimary motorPresent cross-sectional studyBasal ganglia-thalamoBilateral subthalamic stimulationCross-sectional studyHigh beta frequency bandBeta frequency bandsParkinsonian patientsSubthalamic stimulationContralateral sideScreening periodSubthalamic nucleusBradykinesia severityCortical circuitsGamma frequency bandBradykinesiaDiseaseHigh-gamma frequency bandStimulation levelsStimulationCortex
2017
Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation