2022
Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease
Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S. Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease. Neurology And Therapy 2022, 11: 265-282. PMID: 35000133, PMCID: PMC8857357, DOI: 10.1007/s40120-021-00318-4.Peer-Reviewed Original ResearchSupplementary motor areaClinical outcomesParkinson's diseaseDBS locationPostoperative MRIBrain stimulationIntroductionDeep brain stimulationMotor symptom improvementPostoperative clinical outcomesIdiopathic PD patientsPrimary motor cortexOptimal clinical outcomesDeep brain stimulationSTN-DBS outcomesSuperior frontal cortexDBS electrode positionUse of MRIUse of DBSSubcortical volumetryDBS outcomesPD patientsSubcortical targetsSymptom improvementDBS surgeryMotor cortex
2019
Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects
Koirala N, Anwar A, Ciolac D, Glaser M, Pintea B, Deuschl G, Muthuraman M, Groppa S. Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects. Frontiers In Aging Neuroscience 2019, 11: 191. PMID: 31404311, PMCID: PMC6676803, DOI: 10.3389/fnagi.2019.00191.Peer-Reviewed Original ResearchPD patientsHealthy subject groupParkinson's diseaseNetwork-based statisticsDisease patientsHealthy controlsHealthy subjectsWhite matterMiddle-aged healthy controlsNetwork alterationsProbabilistic tractography analysisParkinson's disease patientsWhite matter changesSubject groupsWhite matter microstructural integrityElderly healthy controlsDistinct brain areasPD pathophysiologyWhite matter networksCorticospinal tractCorpus callosumCorona radiataMatter changesPatientsBrain areas
2018
Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease
Muthuraman M, Koirala N, Ciolac D, Pintea B, Glaser M, Groppa S, Tamás G, Groppa S. Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease. Frontiers In Neurology 2018, 9: 711. PMID: 30210436, PMCID: PMC6119713, DOI: 10.3389/fneur.2018.00711.Peer-Reviewed Original ResearchDeep brain stimulationL-dopa therapyParkinson's diseaseBrain stimulationEffects of DBSL-DOPAImpact of DBSNon-motor symptomsEffective treatment optionEvidence-based therapiesEffective pharmacological therapyCentral nervous systemBrain networksPerioperative algorithmSpecific brain networksDopaminergic medicationPharmacological therapyClinical effectsMotor symptomsPD patientsPharmacodynamic effectsPharmacological treatmentTherapy optionsTreatment optionsFirst complication
2017
Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease
Koirala N, Fleischer V, Glaser M, Zeuner K, Deuschl G, Volkmann J, Muthuraman M, Groppa S. Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease. Brain Topography 2017, 31: 311-321. PMID: 28986718, DOI: 10.1007/s10548-017-0597-4.Peer-Reviewed Original ResearchConceptsDeep brain stimulationDiffusion-weighted imagingPostoperative clinical outcomesClinical responseParkinson's diseaseSTN-DBSClinical outcomesSubthalamic nucleusBrain stimulationSubthalamic nucleus deep brain stimulationNon-motor symptomsOptimal clinical responseConnectivity profilesPre-intervention predictorsEvidence-based stateIndependent predictorsPD patientsTherapy optionsClinical effectivenessCingulate gyrusFrontal lobe connectivityCerebral regionsT MRI scannerCerebral networksPrefrontal cortexEffects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation