2019
Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis
Fleischer V, Koirala N, Droby A, Gracien R, Deichmann R, Ziemann U, Meuth S, Muthuraman M, Zipp F, Groppa S. Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis. Therapeutic Advances In Neurological Disorders 2019, 12: 1756286419838673. PMID: 31040880, PMCID: PMC6482642, DOI: 10.1177/1756286419838673.Peer-Reviewed Original ResearchRelapsing-remitting MSEarly relapsing-remitting MSHealthy controlsDisease activityEarly relapsing-remitting multiple sclerosisLongitudinal brain volume changesRelapsing-remitting multiple sclerosisCortical atrophy patternsStructural cortical networksPatients' disease activityNetwork reorganizationBrain volume changesClinical disease manifestationsDetectable atrophyMultiple sclerosisAtrophy patternsDisease manifestationsAtrophy measurementsCortical responsesGray matter networksBrain functionPatientsT MRICortical networksGraph theoretical analysis
2016
Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis
Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth S, Zipp F, Groppa S. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Multiple Sclerosis Journal 2016, 23: 432-441. PMID: 27246143, DOI: 10.1177/1352458516651503.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemMagnetic resonance imagingWhite matterClinical declineClinical impairmentRelapsing-remitting MS patientsEarly multiple sclerosisVoxel-based morphometryTemporo-parietal regionsNeuronal injuryConnectivity patternsMS patientsRemission phaseDisease stageDisease onsetHealthy controlsFunctional declineNervous systemGray matter networksResonance imagingProbabilistic tractographySclerosisStructural connectivityDisease