2022
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine 2022, 14: eabk0135. PMID: 35442704, DOI: 10.1126/scitranslmed.abk0135.Peer-Reviewed Original ResearchConceptsStroke outcomeExperimental strokeGlutamatergic transmissionCortical excitabilityATX concentrationsAstrocyte-specific deletionDifferent time pointsStroke eventsPerisynaptic processesExcess glutamateTherapeutic approachesAnimal modelsTransgenic miceEnzyme autotaxinLPA signalingATX inhibitionPharmacological inhibitionStrokeTranslational potentialTime pointsSingle nucleotide polymorphismsAutotaxinOutcomesExcitabilityInhibition
2019
Cortical Excitability Dynamics During Fear Processing
Chirumamilla V, Gonzalez-Escamilla G, Koirala N, Bonertz T, von Grotthus S, Muthuraman M, Groppa S. Cortical Excitability Dynamics During Fear Processing. Frontiers In Neuroscience 2019, 13: 568. PMID: 31275095, PMCID: PMC6593288, DOI: 10.3389/fnins.2019.00568.Peer-Reviewed Original ResearchFrontal theta powerFear processingTranscranial magnetic stimulationTheta powerVisual cuesWeighted phase lag indexAlpha powerPrefrontal cortexRight dorsomedial prefrontal cortexCortical excitabilityCortical excitability dynamicsAversive unconditioned stimulusInstructed fear paradigmDorsomedial prefrontal cortexFrontal lobeVisual cue onsetStress coping behaviorTheta power changesStructural MRI scanningAlpha frequency bandCue onsetCoping behaviorsFear paradigmOccipital lobeUnconditioned stimulus