2020
Myelination- and immune-mediated MR-based brain network correlates
Cerina M, Muthuraman M, Gallus M, Koirala N, Dik A, Wachsmuth L, Hundehege P, Schiffler P, Tenberge J, Fleischer V, Gonzalez-Escamilla G, Narayanan V, Krämer J, Faber C, Budde T, Groppa S, Meuth S. Myelination- and immune-mediated MR-based brain network correlates. Journal Of Neuroinflammation 2020, 17: 186. PMID: 32532336, PMCID: PMC7293122, DOI: 10.1186/s12974-020-01827-z.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCentral nervous systemCorpus callosumBrain network characteristicsCuprizone dietAnxiety-like behaviorFractional anisotropy valuesDiffusion tensor imagingBackgroundMultiple sclerosisConsistent demyelinationMyelin dynamicsKey anatomical regionsCuprizone modelMyelin lossNeuropsychiatric symptomsAutoimmune diseasesFunctional impairmentNeurodegenerative processesHistopathological basisCortical areasMRI metricsDemyelinationDisease processNervous systemFA reduction
2019
Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects
Koirala N, Anwar A, Ciolac D, Glaser M, Pintea B, Deuschl G, Muthuraman M, Groppa S. Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects. Frontiers In Aging Neuroscience 2019, 11: 191. PMID: 31404311, PMCID: PMC6676803, DOI: 10.3389/fnagi.2019.00191.Peer-Reviewed Original ResearchPD patientsHealthy subject groupParkinson's diseaseNetwork-based statisticsDisease patientsHealthy controlsHealthy subjectsWhite matterMiddle-aged healthy controlsNetwork alterationsProbabilistic tractography analysisParkinson's disease patientsWhite matter changesSubject groupsWhite matter microstructural integrityElderly healthy controlsDistinct brain areasPD pathophysiologyWhite matter networksCorticospinal tractCorpus callosumCorona radiataMatter changesPatientsBrain areas