2022
Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease
Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S. Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease. Neurology And Therapy 2022, 11: 265-282. PMID: 35000133, PMCID: PMC8857357, DOI: 10.1007/s40120-021-00318-4.Peer-Reviewed Original ResearchSupplementary motor areaClinical outcomesParkinson's diseaseDBS locationPostoperative MRIBrain stimulationIntroductionDeep brain stimulationMotor symptom improvementPostoperative clinical outcomesIdiopathic PD patientsPrimary motor cortexOptimal clinical outcomesDeep brain stimulationSTN-DBS outcomesSuperior frontal cortexDBS electrode positionUse of MRIUse of DBSSubcortical volumetryDBS outcomesPD patientsSubcortical targetsSymptom improvementDBS surgeryMotor cortex
2020
Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation
Koirala N, Serrano L, Paschen S, Falk D, Anwar A, Kuravi P, Deuschl G, Groppa S, Muthuraman M. Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation. Scientific Reports 2020, 10: 19241. PMID: 33159098, PMCID: PMC7648837, DOI: 10.1038/s41598-020-74196-5.Peer-Reviewed Original ResearchConceptsMicroelectrode recordingsBackground activityStereotactic magnetic resonance imagingLow beta frequency rangeDeep brain stimulation surgeryBilateral STN-DBSSide effect ratioDeep brain stimulationBeta frequency rangeMagnetic resonance imagingSTN-DBSAwake patientsLead placementSubthalamic nucleusIntraoperative decisionAnatomical sitesBrain stimulationDBS electrodesOptimal target localizationResonance imagingMaximum spike rateBeta rangeSpike ratePatientsImplantationCross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease
Muthuraman M, Bange M, Koirala N, Ciolac D, Pintea B, Glaser M, Tinkhauser G, Brown P, Deuschl G, Groppa S. Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease. Brain 2020, 143: 3393-3407. PMID: 33150359, PMCID: PMC7116448, DOI: 10.1093/brain/awaa297.Peer-Reviewed Original ResearchConceptsDeep brain stimulationBrain stimulationParkinson's diseaseStimulation frequencyCross-frequency couplingMotor symptomsSubthalamic nucleusGamma oscillationsDeep Brain Stimulation FrequencyOscillatory activityPhysiological neural activityMotor function recoveryEffective deep brain stimulationHigh-frequency stimulationPathological oscillatory activityCross-frequency interactionsCortico-subcortical networksDifferent oscillatory activitiesSymptom controlParietal cortex regionsClinical effectsFunction recoverySymptom alleviationMotor impairmentSubcortical regions
2019
Cortical network fingerprints predict deep brain stimulation outcome in dystonia
Gonzalez‐Escamilla G, Muthuraman M, Reich M, Koirala N, Riedel C, Glaser M, Lange F, Deuschl G, Volkmann J, Groppa S. Cortical network fingerprints predict deep brain stimulation outcome in dystonia. Movement Disorders 2019, 34: 1537-1546. PMID: 31433874, DOI: 10.1002/mds.27808.Peer-Reviewed Original ResearchConceptsDeep brain stimulationModerate-outcome groupDystonia patientsEffective evidence-based therapySuperior-outcome groupGlobus pallidus internusGrey matter atrophy patternsEvidence-based therapiesBrain network organizationClinical responseCortical atrophyDBS outcomesIndependent predictorsMotor improvementMulticenter cohortDBS implantationAtrophy patternsPreoperative MRITherapy responseVisuomotor areasCortical thicknessBrain stimulationCortical mantlePatientsUnequivocal predictors
2018
Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease
Muthuraman M, Koirala N, Ciolac D, Pintea B, Glaser M, Groppa S, Tamás G, Groppa S. Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease. Frontiers In Neurology 2018, 9: 711. PMID: 30210436, PMCID: PMC6119713, DOI: 10.3389/fneur.2018.00711.Peer-Reviewed Original ResearchDeep brain stimulationL-dopa therapyParkinson's diseaseBrain stimulationEffects of DBSL-DOPAImpact of DBSNon-motor symptomsEffective treatment optionEvidence-based therapiesEffective pharmacological therapyCentral nervous systemBrain networksPerioperative algorithmSpecific brain networksDopaminergic medicationPharmacological therapyClinical effectsMotor symptomsPD patientsPharmacodynamic effectsPharmacological treatmentTherapy optionsTreatment optionsFirst complication
2017
Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease
Koirala N, Fleischer V, Glaser M, Zeuner K, Deuschl G, Volkmann J, Muthuraman M, Groppa S. Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease. Brain Topography 2017, 31: 311-321. PMID: 28986718, DOI: 10.1007/s10548-017-0597-4.Peer-Reviewed Original ResearchConceptsDeep brain stimulationDiffusion-weighted imagingPostoperative clinical outcomesClinical responseParkinson's diseaseSTN-DBSClinical outcomesSubthalamic nucleusBrain stimulationSubthalamic nucleus deep brain stimulationNon-motor symptomsOptimal clinical responseConnectivity profilesPre-intervention predictorsEvidence-based stateIndependent predictorsPD patientsTherapy optionsClinical effectivenessCingulate gyrusFrontal lobe connectivityCerebral regionsT MRI scannerCerebral networksPrefrontal cortexEffects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation
2016
Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;
Koirala N, Fleischer V, Granert O, Deuschl G, Muthuraman M, Groppa S. Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2016, 2016: 5533-5536. PMID: 28269510, DOI: 10.1109/embc.2016.7591980.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDeep brain stimulationSTN-DBSParkinson's diseaseDiffusion tensor imagingBrain stimulationProbabilistic tractographyActive DBS contactsPostoperative clinical outcomesPrimary motor cortexStandard therapeutic optionIdiopathic Parkinson's diseaseCortico-spinal tractSubcortical seedsClinical outcomesTherapeutic optionsDBS contactsMotor cortexDBS treatmentUniversity HospitalSubthalamic nucleusMotor areaPremotor regionsStimulation siteTensor imaging