Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy
Alexandru H, Muthuraman M, Chirumamilla V, Koirala N, Paktas B, Deuschl G, Zeuner K, Groppa S. Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLOS ONE 2016, 11: e0168652. PMID: 27992533, PMCID: PMC5161386, DOI: 10.1371/journal.pone.0168652.Peer-Reviewed Original ResearchConceptsBenign essential blepharospasmHemifacial spasmBoNT therapyCortical thicknessBEB patientsHealthy controlsTemporal poleCommon hyperkinetic movement disordersStandard evidence-based treatmentGroup of patientsBotulinum neurotoxin therapyHyperkinetic movement disordersPrimary motor cortexDifferent pathophysiological mechanismsLower cortical thicknessEvidence-based treatmentsFacial musclesPre-supplementary motor areaRight superior frontal regionsGroup of ageLeft lingual gyrusSuperior frontal regionsGray matter integrityContrary patientsNeurotoxin therapy