2020
Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19
Yap JKY, Moriyama M, Iwasaki A. Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19. The Journal Of Immunology 2020, 205: ji2000513. PMID: 32493814, PMCID: PMC7343621, DOI: 10.4049/jimmunol.2000513.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsAntiviral AgentsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentHumansImmunity, InnateInflammasomesIntercellular Signaling Peptides and ProteinsMacrophages, AlveolarPandemicsPneumonia, ViralPyroptosisSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSignal TransductionConceptsSevere acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infectionSevere acute respiratory syndrome-related coronavirus 2Coronavirus disease 2019 (COVID-19) patientsSevere coronavirus disease 2019Coronavirus 2 infectionAvailable pharmaceutical agentsCoronavirus disease 2019Innate immune pathwaysClinical outcomesCoronavirus 2Inflammatory responseCellular pyroptosisDisease 2019Downstream cytokinesInflammasome activationInflammasome pathwayTherapeutic targetImmune pathwaysPromising targetPharmaceutical agentsCOVID-19PyroptosisPatientsCytokinesInflammasome
2019
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature Communications 2019, 10: 4624. PMID: 31604929, PMCID: PMC6789137, DOI: 10.1038/s41467-019-12632-5.Peer-Reviewed Original ResearchConceptsMitochondrial DNANonstructural protein 1Cytosolic mitochondrial DNAMtDNA releaseInfluenza virus M2Antiviral immune responseImportance of DNAVirus M2 proteinImmune responseViroporin activityMAVS-dependent mannerTriggers translocationVirus replicationCytosolic mtDNAAntiviral signalingVirus M2M2 proteinRNA virusesInnate immune responseMtDNAInfluenza virus replicationInfluenza virusNeighboring cellsProtein 1Gap junctions