High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection
Nagai M, Moriyama M, Ishii C, Mori H, Watanabe H, Nakahara T, Yamada T, Ishikawa D, Ishikawa T, Hirayama A, Kimura I, Nagahara A, Naito T, Fukuda S, Ichinohe T. High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection. Nature Communications 2023, 14: 3863. PMID: 37391427, PMCID: PMC10313692, DOI: 10.1038/s41467-023-39569-0.Peer-Reviewed Original ResearchConceptsTakeda G protein-coupled receptor 5Gut microbiota-dependent mannerSARS-CoV-2 infectionMicrobiota-dependent mannerIncrease host resistanceLethal SARS-CoV-2 infectionDeoxycholic acidSevere acute respiratory syndrome coronavirus 2Neutrophil-dependent tissue damageAcute respiratory syndrome coronavirus 2Influenza virusRespiratory syndrome coronavirus 2G protein-coupled receptor 5Farnesoid X receptor agonistCOVID-19 patientsExposure of miceInfluenza virus infectionSyndrome coronavirus 2Coronavirus disease 2019Host resistanceX receptor agonistCertain bile acidsBasal body temperatureSARS-CoV-2Body temperature