2020
Influenza Virus-Induced Oxidized DNA Activates Inflammasomes
Moriyama M, Nagai M, Maruzuru Y, Koshiba T, Kawaguchi Y, Ichinohe T. Influenza Virus-Induced Oxidized DNA Activates Inflammasomes. IScience 2020, 23: 101270. PMID: 32592999, PMCID: PMC7293844, DOI: 10.1016/j.isci.2020.101270.Peer-Reviewed Original ResearchPB1-F2 proteinOxidized DNAViral proteinsMitochondrial reactive oxygen species productionDNA releaseInfluenza virus M2IL-1β secretionMitochondrial ROS productionIon channel activityReactive oxygen species productionMitochondrial localizationIntracellular ionic balanceAntioxidant Mito-TEMPOOxygen species productionNLRP3 inflammasome activationVirus M2Inflammasome activationM2 proteinReceptor familyNOD-like receptor familyProteinInfluenza viral proteinsMito-TEMPOChannel activityROS production
2019
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature Communications 2019, 10: 4624. PMID: 31604929, PMCID: PMC6789137, DOI: 10.1038/s41467-019-12632-5.Peer-Reviewed Original ResearchConceptsMitochondrial DNANonstructural protein 1Cytosolic mitochondrial DNAMtDNA releaseInfluenza virus M2Antiviral immune responseImportance of DNAVirus M2 proteinImmune responseViroporin activityMAVS-dependent mannerTriggers translocationVirus replicationCytosolic mtDNAAntiviral signalingVirus M2M2 proteinRNA virusesInnate immune responseMtDNAInfluenza virus replicationInfluenza virusNeighboring cellsProtein 1Gap junctionsSevere Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
Chen I, Moriyama M, Chang M, Ichinohe T. Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome. Frontiers In Microbiology 2019, 10: 50. PMID: 30761102, PMCID: PMC6361828, DOI: 10.3389/fmicb.2019.00050.Peer-Reviewed Original ResearchNLRP3 inflammasome activationIL-1β secretionInflammasome activationNLRP3 inflammasomeProinflammatory cytokines interleukin-1 betaNOD-like receptor familyCytokines interleukin-1 betaIon channel activitySevere acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusLipopolysaccharide-primed macrophagesInterleukin-1 betaChannel activityInfluenza virus M2IL-18Mitochondrial reactive oxygen speciesNLRP3SARS-CoV 3a proteinReactive oxygen speciesReceptor familySecretionInflammasomeViral proteinsVirus M2Activation